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Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity
Includes bibliographical references (leaves 178-191).
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2014
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| _version_ | 1867613858883960832 |
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| access_status_str | Open Access |
| author | Mabotha, Tebogo E |
| author_browse | Mabotha, Tebogo E |
| author_facet | Mabotha, Tebogo E |
| author_sort | Mabotha, Tebogo E |
| collection | Thesis |
| description | Includes bibliographical references (leaves 178-191). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6326 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:42:50.182Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6326 Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity Mabotha, Tebogo E Chemistry Includes bibliographical references (leaves 178-191). An interfacial method was developed in order to investigate the role lipids might play in haemozoin biosynthesis. Infrared and X-ray diffraction measurements demonstrated that β-haematin, a synthetic counterpart of haemozoin, forms efficiently at pentanol/water, octanol/water and lipid/water interfaces, but to a lesser extent at toluene/water interface under physiological conditions of pH and temperature and does not form at all in the absence of the interface. 2014-08-13T14:26:55Z 2014-08-13T14:26:55Z 2007 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6326 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Mabotha, Tebogo E Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity |
| thesis_degree_str | Doctoral |
| title | Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity |
| title_full | Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity |
| title_fullStr | Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity |
| title_full_unstemmed | Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity |
| title_short | Haemozoin formation, effects of chloroquine on iron distribution in Plasmodium falciparum and the correlation of thermordynamic and structural factors with 4-aminoquinoline activity |
| title_sort | haemozoin formation effects of chloroquine on iron distribution in plasmodium falciparum and the correlation of thermordynamic and structural factors with 4 aminoquinoline activity |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6326 |
| work_keys_str_mv | AT mabothatebogoe haemozoinformationeffectsofchloroquineonirondistributioninplasmodiumfalciparumandthecorrelationofthermordynamicandstructuralfactorswith4aminoquinolineactivity |