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Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis
Includes abstract.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2014
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| _version_ | 1867613152919683072 |
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| access_status_str | Open Access |
| author | Mohajane, Mamohale |
| author2 | Jackson, Graham Ellis |
| author_browse | Jackson, Graham Ellis Mohajane, Mamohale |
| author_facet | Jackson, Graham Ellis Mohajane, Mamohale |
| author_sort | Mohajane, Mamohale |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6340 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:35.974Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6340 Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis Mohajane, Mamohale Jackson, Graham Ellis Chemistry Includes abstract. Includes bibliographical references. The H⁺ and Cu²⁺ equilibria of four glycine peptides (glycyl-glycine, glycyl-L-leucine, glycyl-L-phenylalanine and glycyl-L-histidine) and four sarcosine peptides (sarcosylglycine, sarcosyl-L-leucine, sarcosyl-L-phenylalanine and sarcosyl-L-histidine) have been studied using glass electrode potentiometry and isothermal titration calorimetry at 25 °C and an ionic strength 0.15 M (NaCl). The terminal amine of the sarcosine peptides is more basic than the glycine analogues. The methyl group on the terminal amine (for sarcosine peptides) does not affect the stability constants of the ML species, significantly. Log K for ML species for all the Cu(II)/peptides complexes ranged between 5.79 and 6.54, except for glycyl-L-histidine that showed log KML = 9.16. Heat accompanying the formation of ML for all the species ranged between -5.1 kcal mol⁻¹ and-6.6 kcal mol⁻¹, except for glycyl-L-histidine that showed ΔHML = -3.6 kcal.mol⁻¹. Structures for the different species in solution were postulated based on nuclear magnetic resonance and ultraviolet-visible spectrophotometry data. Molecular mechanics was used to investigate the possible structures. The minimum energy of the trans form of most the complexes was less than the cis form of the complexes. 2014-08-13T14:27:22Z 2014-08-13T14:27:22Z 2013 Master Thesis Masters MSc http://hdl.handle.net/11427/6340 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Mohajane, Mamohale Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis |
| thesis_degree_str | Master's |
| title | Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis |
| title_full | Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis |
| title_fullStr | Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis |
| title_full_unstemmed | Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis |
| title_short | Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis |
| title_sort | dipeptides as potential anti flammatory drugs for rheumatoid arthritis |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6340 |
| work_keys_str_mv | AT mohajanemamohale dipeptidesaspotentialantiflammatorydrugsforrheumatoidarthritis |