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Antimalarials based on the arylpiperazine privileged substructure
Includes bibliographical references (leaves 118-124).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867614005375270912 |
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| access_status_str | Open Access |
| author | Molyneaux, Carrie-Anne |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Molyneaux, Carrie-Anne |
| author_facet | Chibale, Kelly Molyneaux, Carrie-Anne |
| author_sort | Molyneaux, Carrie-Anne |
| collection | Thesis |
| description | Includes bibliographical references (leaves 118-124). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6342 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:45:09.887Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6342 Antimalarials based on the arylpiperazine privileged substructure Molyneaux, Carrie-Anne Chibale, Kelly Chemistry Includes bibliographical references (leaves 118-124). Based on a previous study, arylpiperazines (2-chlorophenylpiperazine, 2-ethoxyphenylpiperazine and phenylpiperazine) were found to be significantly more potent against the chloroquine-resistant (K1) strain than against the chloroquine-sensitive(DIO) strain. In other studies, 8-hydroxy-2-(di-n-propylamino)tetralin (8-0H-DPAT) has been identified as a potential antimalarial agent for the inhibition of the 5-hydroxytryptamine type 1A receptor in Plasmodium falciparum. A number of arylpiperazines are also known to target this receptor in other systems. Coupled with the potential role of arylpiperazines as replacements for the antimalarial 8-OH-OPA T, these results prompted a further investigation into the antiplasmodial properties of a broader range of simple un substituted and substituted arylpiperazines against a broader range of chloroquine-sensitive and chloroquine-resistant strains of PlasmodiumJalciparum. 2014-08-13T14:27:27Z 2014-08-13T14:27:27Z 2005 Master Thesis Masters MSc http://hdl.handle.net/11427/6342 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Molyneaux, Carrie-Anne Antimalarials based on the arylpiperazine privileged substructure |
| thesis_degree_str | Master's |
| title | Antimalarials based on the arylpiperazine privileged substructure |
| title_full | Antimalarials based on the arylpiperazine privileged substructure |
| title_fullStr | Antimalarials based on the arylpiperazine privileged substructure |
| title_full_unstemmed | Antimalarials based on the arylpiperazine privileged substructure |
| title_short | Antimalarials based on the arylpiperazine privileged substructure |
| title_sort | antimalarials based on the arylpiperazine privileged substructure |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6342 |
| work_keys_str_mv | AT molyneauxcarrieanne antimalarialsbasedonthearylpiperazineprivilegedsubstructure |