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Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613231330099200 |
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| access_status_str | Open Access |
| author | October, Natasha |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly October, Natasha |
| author_facet | Chibale, Kelly October, Natasha |
| author_sort | October, Natasha |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6353 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:51.499Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6353 Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum October, Natasha Chibale, Kelly Chemistry Includes bibliographical references. For many years malaria has been a major cause of human suffering. Despite significant advances in understanding the disease and the parasite, malaria still remains one of the leading causes of morbidity and mortality, particularly in the tropics. Approximately 500 million people are afflicted and almost 3 million people die from the disease annually. Of the four causative species, Plasmodium falciparum is the most lethal. Recent trends indicate rapid emergence of drug-resistent and more virulent strains of the parasite to further intensify the problem. The choice of therapies currently available for the treatment of malaria is highly limited, and several of these may eventually be lost or compromised due to drug resistance. New antimalarial drugs with proven clinical efficacy against current drug-resistance cases of malaria including Plasmodium falciparum infections is critical to combact the disease and cope with the problem of further development or resistance. 2014-08-13T14:28:56Z 2014-08-13T14:28:56Z 2006 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6353 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry October, Natasha Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum |
| thesis_degree_str | Doctoral |
| title | Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum |
| title_full | Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum |
| title_fullStr | Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum |
| title_full_unstemmed | Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum |
| title_short | Design, synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite Plasmodium falciparum |
| title_sort | design synthesis and evaluation of potential dual drugs targeting the haemoglobin degradation pathway in the malaria parasite plasmodium falciparum |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6353 |
| work_keys_str_mv | AT octobernatasha designsynthesisandevaluationofpotentialdualdrugstargetingthehaemoglobindegradationpathwayinthemalariaparasiteplasmodiumfalciparum |