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Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation.
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613225263038464 |
|---|---|
| access_status_str | Open Access |
| author | Pillay, Pamisha |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Pillay, Pamisha |
| author_facet | Chibale, Kelly Pillay, Pamisha |
| author_sort | Pillay, Pamisha |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6357 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:45.765Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6357 Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. Pillay, Pamisha Chibale, Kelly Maharaj, Vinesh Chemistry Includes abstract. Includes bibliographical references. Trema orientalis, a widely distributed evergreen tree with various medicinal properties including the treatment of malaria, was investigated as a potential source of new antimalarial lead compounds. Organic extracts of the young growing twigs of T. orientalis were reproducibly shown to be active against the chloroquine-sensitive (D10) and chloroquine resistant (K1) strains of Plasmodium falciparum. The 8-O-4' oxyneolignans, dadahols A and B, were identified as the major active compounds using two bioassay-guided fractionation approaches. The new accelerated “HPLC biogram” methodology allowed for early recognition of the active compounds in the complex plant extract, requiring considerably less time and material compared to the classical reiterative approach. 2014-08-13T14:29:27Z 2014-08-13T14:29:27Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6357 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Pillay, Pamisha Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. |
| thesis_degree_str | Doctoral |
| title | Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. |
| title_full | Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. |
| title_fullStr | Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. |
| title_full_unstemmed | Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. |
| title_short | Antiplasmodial neolignans from Trema orientalis : identification, synthesis and analogue generation. |
| title_sort | antiplasmodial neolignans from trema orientalis identification synthesis and analogue generation |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6357 |
| work_keys_str_mv | AT pillaypamisha antiplasmodialneolignansfromtremaorientalisidentificationsynthesisandanaloguegeneration |