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Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents
Bibliography: leaves 108-113.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2014
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| _version_ | 1867613323296505856 |
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| access_status_str | Open Access |
| author | Haupt, Hayley Claire |
| author2 | Chibale, Kelly |
| author_browse | Chibale, Kelly Haupt, Hayley Claire |
| author_facet | Chibale, Kelly Haupt, Hayley Claire |
| author_sort | Haupt, Hayley Claire |
| collection | Thesis |
| description | Bibliography: leaves 108-113. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6974 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:17.944Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6974 Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents Haupt, Hayley Claire Chibale, Kelly Chemistry Bibliography: leaves 108-113. Compounds containing the quinoline and acridine moieties have been utilized extensively in the search for new antiprotozoal and multidrug resistance reversal agents. Hence, these moieties formed the basis for the synthesis of new compounds. New sulfonamides, ureas and amine analogues were synthesized and evaluated for inhibitory activity against trypanothione reductase (TryR), in vitro activity against the causative agents of trypanosomiasis, leishmaniasis as well as chloroquine-sensitive and resistant malaria. Some were also evaluated as potential tumour multidrug resistance reversal agents. 2014-09-08T09:57:25Z 2014-09-08T09:57:25Z 2002 Master Thesis Masters MSc http://hdl.handle.net/11427/6974 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Haupt, Hayley Claire Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents |
| thesis_degree_str | Master's |
| title | Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents |
| title_full | Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents |
| title_fullStr | Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents |
| title_full_unstemmed | Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents |
| title_short | Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents |
| title_sort | exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6974 |
| work_keys_str_mv | AT haupthayleyclaire exploringthepotentialofchloroquineandquinacrinederivativesasnewantiprotozoalandtumourdrugresistancereversalagents |