Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
South African marine compounds as anticancer agents
Includes bibliographical references (leaves 149-163).
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613300647264256 |
|---|---|
| access_status_str | Open Access |
| author | Whibley, Catherine Evelyn |
| author2 | Hendricks, Denver T |
| author_browse | Hendricks, Denver T Whibley, Catherine Evelyn |
| author_facet | Hendricks, Denver T Whibley, Catherine Evelyn |
| author_sort | Whibley, Catherine Evelyn |
| collection | Thesis |
| description | Includes bibliographical references (leaves 149-163). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/8393 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:57.504Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Medical Biochemistry |
| publisherStr | Division of Medical Biochemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/8393 South African marine compounds as anticancer agents Whibley, Catherine Evelyn Hendricks, Denver T Davies-Coleman, Michael T Medical Biochemistry Includes bibliographical references (leaves 149-163). Oesophageal cancer is the most common cause of cancer related deaths among black males in South Africa. Currently there are very limited treatment options, and patients have a very poor prognosis, due in part to the late stage at which this cancer is usually detected. In this thesis we describe the establishment of a screening assay using an oesophageal cancer cell line as a model. It was our hope that this screen would allow us to identify compounds which have activity against oesophageal cancer, that could be used as lead agents for further development of chemotherapeutic agents. Once our screen was established, we tested a wide range of extracts from southern African marine organisms, supplied by our collaborators from Rhodes University, South Africa. The marine environment represents a rich, untapped repository of novel and interesting compounds, and through our collaboration we had access to a wide range of marine-derived extracts and compounds. During the course of this project we provided screening data to assist in activity-directed fractionation from five active marine extracts, giving rise to 15 compounds of varying activity. These included several groups of novel active compounds such as the makaluvic acids from the sponge Strongylodesma aliwaliensis and the malonganenones from the octocoral Leptogorgia gi/christii. The identification of a number of novel, active compounds through our screening program highlights the potential of marine organisms from the southern African coast as a source of novel drug leads. 2014-10-11T12:17:01Z 2014-10-11T12:17:01Z 2006 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/8393 eng application/pdf Division of Medical Biochemistry Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medical Biochemistry Whibley, Catherine Evelyn South African marine compounds as anticancer agents |
| thesis_degree_str | Doctoral |
| title | South African marine compounds as anticancer agents |
| title_full | South African marine compounds as anticancer agents |
| title_fullStr | South African marine compounds as anticancer agents |
| title_full_unstemmed | South African marine compounds as anticancer agents |
| title_short | South African marine compounds as anticancer agents |
| title_sort | south african marine compounds as anticancer agents |
| topic | Medical Biochemistry |
| url | http://hdl.handle.net/11427/8393 |
| work_keys_str_mv | AT whibleycatherineevelyn southafricanmarinecompoundsasanticanceragents |