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Isolation and characterisation of antibiotic-producing marine actinomycetes
Bibliography: leaves 94-102.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2014
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| _version_ | 1867613967370682368 |
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| access_status_str | Open Access |
| author | Porter, Donovan Stuart |
| author2 | Meyers, Paul |
| author_browse | Meyers, Paul Porter, Donovan Stuart |
| author_facet | Meyers, Paul Porter, Donovan Stuart |
| author_sort | Porter, Donovan Stuart |
| collection | Thesis |
| description | Bibliography: leaves 94-102. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/8591 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:44:33.643Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/8591 Isolation and characterisation of antibiotic-producing marine actinomycetes Porter, Donovan Stuart Meyers, Paul Cell Biology Bibliography: leaves 94-102. Resistance to antibiotics poses a serious threat to healthcare and new drugs are needed. This is especially true for tuberculosis (TB), which is at epidemic levels in South Africa. Multidrug-resistance in Mycobacterium tuberculosis makes TB more difficult and expensive to treat and increases mortality rates. The surfaces of 12 seaweed species found in South African coastal waters were screened for the presence of antibiotic-producing actinomycetes. Of the 67 strains isolated, 26 exhibited antibacterial activity against Mycobacterium aurum A+ and for Enterococcus faecium VanA. These actinomycete strains were physiologically characterised. Three strains showing very strong antibacterial activity were further characterised by the use of chemical taxonomy, DNA sequencing and scanning electron microscopy and were shown to belong to the genus Streptomyces. A strain not showing activity was shown by the same methods to belong to the genus Micromonospora. Partial purification of the active compounds was carried out on the three strains exhibiting strong antibacterial activity. All were shown to produce moderately to highly polar compounds. 2014-10-18T05:54:58Z 2014-10-18T05:54:58Z 2003 Master Thesis Masters MSc http://hdl.handle.net/11427/8591 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Porter, Donovan Stuart Isolation and characterisation of antibiotic-producing marine actinomycetes |
| thesis_degree_str | Master's |
| title | Isolation and characterisation of antibiotic-producing marine actinomycetes |
| title_full | Isolation and characterisation of antibiotic-producing marine actinomycetes |
| title_fullStr | Isolation and characterisation of antibiotic-producing marine actinomycetes |
| title_full_unstemmed | Isolation and characterisation of antibiotic-producing marine actinomycetes |
| title_short | Isolation and characterisation of antibiotic-producing marine actinomycetes |
| title_sort | isolation and characterisation of antibiotic producing marine actinomycetes |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/8591 |
| work_keys_str_mv | AT porterdonovanstuart isolationandcharacterisationofantibioticproducingmarineactinomycetes |