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Comparative molecular genetics of the German Shepherd dog
Includes bibliographical references (leaves 105-111).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Chemical Pathology
2014
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| _version_ | 1867613335247126528 |
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| access_status_str | Open Access |
| author | Coutts, Natalie June |
| author2 | Harley, Eric |
| author_browse | Coutts, Natalie June Harley, Eric |
| author_facet | Harley, Eric Coutts, Natalie June |
| author_sort | Coutts, Natalie June |
| collection | Thesis |
| description | Includes bibliographical references (leaves 105-111). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/8622 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:28.941Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Chemical Pathology |
| publisherStr | Division of Chemical Pathology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/8622 Comparative molecular genetics of the German Shepherd dog Coutts, Natalie June Harley, Eric Chemical Pathology Includes bibliographical references (leaves 105-111). Microsatellite markers were used to measure genetic diversity and population differentiation within and between domestic dog breeds. The German Shepherd Dog was compared with typical outbred mongrel dogs, Dachshunds, Staffordshire Bull Terriers and a cohort of other pedigreed dogs representing 30 recognised breeds. Although archaeological records report that grey wolves (Canis lupus) were domesticated approximately 14 000 years ago, mtDNA analysis suggests that domestic dogs (Canis familiaris) and grey wolves diverged in multiple events over 100 000 years ago. Subsequently, the movement of humans and their dogs resulted in extensive gene flow between dog populations for thousands of years. Breeding practices to obtain distinctive pnenotypic uniformity were recently introduced, resulting in pure-bred dogs becoming essentially closed gene pools. However, further mtDNA analyses have reported unexpectedly high levels of variability, supported by microsatellite loci with heterogeneities of between 36% and 55% being reported for some dog breeds. Microsatellite analyses of 15 polymorphic canine loci are reported. German Shepherd Dogs and outbred mongrel dogs expressed diversity values of 4.0 alleles per locus in the former and 6.4 in the later (corrected for population size by jack-knifing with 1 000 pseudoreplications), with expected heterozygosities of 62% and 83%, respectively. German Shepherd Dogs showed a moderate loss of genetic diversity relative to outbred dogs, but not sufficient to describe the breed as highly inbred. However, in comparison with other pure-bred dogs examined, they expressed the least genetic diversity, with Dachshunds having 5.2, Staffordshire Bull Terriers 4.8 and the composite group of pedigreed dogs 6.0 alleles per locus, with expected heterozygosities of 72%, 67% and 80%, respectively. Significant population differentiation (GST = 0.103; RST = 0.058) between German Shepherd Dogs and the outbred dogs illustrates the effect of genetic drift since the breed was established just over 100 years ago. This study would benefit future breeding programs, as management should be facilitated by knowledge of relative measures of inbreeding and differentiation, especially between various separate breeding stocks within the breed. 2014-10-20T07:14:45Z 2014-10-20T07:14:45Z 2004 Master Thesis Masters MMed http://hdl.handle.net/11427/8622 eng application/pdf Division of Chemical Pathology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Chemical Pathology Coutts, Natalie June Comparative molecular genetics of the German Shepherd dog |
| thesis_degree_str | Master's |
| title | Comparative molecular genetics of the German Shepherd dog |
| title_full | Comparative molecular genetics of the German Shepherd dog |
| title_fullStr | Comparative molecular genetics of the German Shepherd dog |
| title_full_unstemmed | Comparative molecular genetics of the German Shepherd dog |
| title_short | Comparative molecular genetics of the German Shepherd dog |
| title_sort | comparative molecular genetics of the german shepherd dog |
| topic | Chemical Pathology |
| url | http://hdl.handle.net/11427/8622 |
| work_keys_str_mv | AT couttsnataliejune comparativemoleculargeneticsofthegermanshepherddog |