Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design
Includes bibliographical references.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Immunology
2014
|
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613898773889024 |
|---|---|
| access_status_str | Open Access |
| author | Jacob, Rajesh Abraham |
| author2 | Dorfman, Jeffrey |
| author_browse | Dorfman, Jeffrey Jacob, Rajesh Abraham |
| author_facet | Dorfman, Jeffrey Jacob, Rajesh Abraham |
| author_sort | Jacob, Rajesh Abraham |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/8707 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:43:28.224Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Immunology |
| publisherStr | Division of Immunology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/8707 Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design Jacob, Rajesh Abraham Dorfman, Jeffrey Includes bibliographical references. Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine. The Membrane Proximal External Region (MPER) within the HIV- 1 gp41 envelope is a promising vaccine target. The MPER is highly conserved, functionally constrained, facilitates virus fusion and is targeted by broadly neutralizing monoclonal antibodies. The objectives of this research were 1) To evaluate the neutralization breadth of antibodies induced by epitopes within the MPER compared to the PG9/16-site in chronically HIV-1-infected individuals, 2) to identify neutralization resistant HIV-1 isolates (using plasma samples infected with the same subtype) and to characterize their sensitivity to anti-MPER antibodies and 3) to determine the accessibility of the MPER to HIV-1 induced polyclonal anti-MPER antibodies in a highly neutralization resistant virus (253-11; CRF02_AG subtype). 2014-10-21T13:47:48Z 2014-10-21T13:47:48Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/8707 eng application/pdf Division of Immunology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Jacob, Rajesh Abraham Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design |
| thesis_degree_str | Doctoral |
| title | Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design |
| title_full | Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design |
| title_fullStr | Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design |
| title_full_unstemmed | Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design |
| title_short | Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design |
| title_sort | evaluating the neutralizing antibody response to hiv 1 membrane proximal external regional implications for vaccine design |
| url | http://hdl.handle.net/11427/8707 |
| work_keys_str_mv | AT jacobrajeshabraham evaluatingtheneutralizingantibodyresponsetohiv1membraneproximalexternalregionalimplicationsforvaccinedesign |