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Development of new bioorganometallic metallodendrimers as in vitro anticancer agents
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613210861895680 |
|---|---|
| access_status_str | Open Access |
| author | Govender, Preshendren |
| author2 | Smith, Gregory S |
| author_browse | Govender, Preshendren Smith, Gregory S |
| author_facet | Smith, Gregory S Govender, Preshendren |
| author_sort | Govender, Preshendren |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/8720 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:31.718Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/8720 Development of new bioorganometallic metallodendrimers as in vitro anticancer agents Govender, Preshendren Smith, Gregory S Clinical Laboratory Sciences Includes bibliographical references. The clinical success of cisplatin and its derivatives for the treatment of different cancers has had a profound effect on the use of metal-containing agents in medicine. Despite the successes, the drawbacks of platinum-based therapy, such as drug resistance, toxicity and the emergence of unwanted side effects, have bred a need for effective and novel anticancer agents. Hence, the design and study of bioorganometallic complexes as potential therapeutic agents may eventually lead to the identification of new drug candidates. The purpose of this study was to synthesize and characterize a series of polynuclear transition-metal-containing complexes based on a (poly)propyleneimine dendritic scaffold, and investigate the in vitro antiproliferative activity of these complexes. 2014-10-21T14:23:13Z 2014-10-21T14:23:13Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/8720 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Clinical Laboratory Sciences Govender, Preshendren Development of new bioorganometallic metallodendrimers as in vitro anticancer agents |
| thesis_degree_str | Doctoral |
| title | Development of new bioorganometallic metallodendrimers as in vitro anticancer agents |
| title_full | Development of new bioorganometallic metallodendrimers as in vitro anticancer agents |
| title_fullStr | Development of new bioorganometallic metallodendrimers as in vitro anticancer agents |
| title_full_unstemmed | Development of new bioorganometallic metallodendrimers as in vitro anticancer agents |
| title_short | Development of new bioorganometallic metallodendrimers as in vitro anticancer agents |
| title_sort | development of new bioorganometallic metallodendrimers as in vitro anticancer agents |
| topic | Clinical Laboratory Sciences |
| url | http://hdl.handle.net/11427/8720 |
| work_keys_str_mv | AT govenderpreshendren developmentofnewbioorganometallicmetallodendrimersasinvitroanticanceragents |