Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples
Includes bibliographical references.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Virology
2014
|
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613208736432128 |
|---|---|
| access_status_str | Open Access |
| author | Jaumdally, Shameem Zaer |
| author2 | Passmore, Jo-Ann |
| author_browse | Jaumdally, Shameem Zaer Passmore, Jo-Ann |
| author_facet | Passmore, Jo-Ann Jaumdally, Shameem Zaer |
| author_sort | Jaumdally, Shameem Zaer |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/8796 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:29.432Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Division of Virology |
| publisherStr | Division of Virology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/8796 Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples Jaumdally, Shameem Zaer Passmore, Jo-Ann Gumbi, Pamela Little, Francesca Includes bibliographical references. The biological correlates of protection against HIV infection remain poorly characterized, hindering the development of an effective prevention strategy. Studies of individuals who resist HIV infection or progress more slowly after being infected are important for the conception of appropriate approaches for mimicking the effective responses against HIV infection or progression. The role of immune activation and chronic inflammation in the modulation of HIV acquisition risk and/or rate of HIV disease progression has been proposed as one of the most important mechanisms determining risk and pathogenesis but is not fully understood. A state of immune quiescence has been associated with protection against HIV infection and slower disease progression. To explore potential risk factors associated with HIV transmission and HIV disease progression, this dissertation investigates the relationship between clinical and biological biomarkers and resistance to HIV infection or disease progression (including viral load, CD4 counts, cellular activation, soluble inflammatory and regulatory cytokines, and HIV co-receptor expression) in stable long-term HIV seroconcordant and serodiscordant couples. 2014-10-27T19:29:22Z 2014-10-27T19:29:22Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/8796 eng application/pdf Division of Virology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Jaumdally, Shameem Zaer Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples |
| thesis_degree_str | Doctoral |
| title | Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples |
| title_full | Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples |
| title_fullStr | Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples |
| title_full_unstemmed | Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples |
| title_short | Impact of immune activation and inflammation on the susceptibility to HIV infection and disease progression in HIV serodiscordant and seroconcordant couples |
| title_sort | impact of immune activation and inflammation on the susceptibility to hiv infection and disease progression in hiv serodiscordant and seroconcordant couples |
| url | http://hdl.handle.net/11427/8796 |
| work_keys_str_mv | AT jaumdallyshameemzaer impactofimmuneactivationandinflammationonthesusceptibilitytohivinfectionanddiseaseprogressioninhivserodiscordantandseroconcordantcouples |