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Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis)
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Molecular and Cell Biology
2014
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| _version_ | 1867613196240551936 |
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| access_status_str | Open Access |
| author | Curry, Lyle |
| author2 | Illing, Nicola |
| author_browse | Curry, Lyle Illing, Nicola |
| author_facet | Illing, Nicola Curry, Lyle |
| author_sort | Curry, Lyle |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9112 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:17.361Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9112 Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis) Curry, Lyle Illing, Nicola Jacobs, David S Includes bibliographical references. The Myeloid ecotropic insertion site 2 (Meis2) gene is an important transcriptional regulator involved in the pattering of the limb during vertebrate development. In the forelimbs (wings) of bats the expression Meis2 was shown to be differentially expressed when compared to mice forelimbs. Meis2 was found to be present in the interdigital webbing of the autopod (hand) of the developing bat forelimb. In both the mouse and the bat, two separate transcripts were discovered to be expressed from the 3’and 5’ region of the Meis2 locus. The 3’ transcripts corresponded to annotated Meis2 mRNA transcripts, the 5’ transcript corresponded to an mRNA transcript that did not code for any known protein. The 5’ transcript was thought to be a long non-coding RNA and was termed lncMeis2. In this study Random Amplification of cDNA Ends (RACE) analysis was used to identify the RNA transcripts expressed from the Meis2 locus and to verify the presence of lncMeis2. RACE was performed on the heads and forelimbs of the Natal Long-fingered bat (Miniopterus natalensis) and the mouse (Mus musculus) and the products sequenced and aligned to the mouse genome for verification. 2014-11-05T03:47:00Z 2014-11-05T03:47:00Z 2014 Master Thesis Masters MSc http://hdl.handle.net/11427/9112 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Curry, Lyle Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis) |
| thesis_degree_str | Master's |
| title | Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis) |
| title_full | Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis) |
| title_fullStr | Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis) |
| title_full_unstemmed | Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis) |
| title_short | Characterization of transcripts expressed from the Meis2 locus in the Natal Long-fingered bat (Miniopterus natalensis) |
| title_sort | characterization of transcripts expressed from the meis2 locus in the natal long fingered bat miniopterus natalensis |
| url | http://hdl.handle.net/11427/9112 |
| work_keys_str_mv | AT currylyle characterizationoftranscriptsexpressedfromthemeis2locusinthenatallongfingeredbatminiopterusnatalensis |