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Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents
Includes bibliographical references (leaves 107-111).
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613321088204800 |
|---|---|
| access_status_str | Open Access |
| author | Qwebani, Tozama |
| author2 | Hunter, Roger |
| author_browse | Hunter, Roger Qwebani, Tozama |
| author_facet | Hunter, Roger Qwebani, Tozama |
| author_sort | Qwebani, Tozama |
| collection | Thesis |
| description | Includes bibliographical references (leaves 107-111). |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9281 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:34:14.045Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9281 Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents Qwebani, Tozama Hunter, Roger Caira, Mino R Chemistry Includes bibliographical references (leaves 107-111). The first part of the thesis describes synthesis of 10-( 4-methoxyphenyl)-4,5,9-trithia-deca- 1 ,6-diene (25) as an ajoene mimic and as a mixture of EIZ-geometrical isomers using new synthetic methodology. 4,5,9-trithia-dodeca-1,6-diene 9-oxide (43), 4,5,9-trithia-dodeca-,6- ene 9-oxide (44) and 2,3,7-trithia-deca-4-ene 7-oxide (45) were also successfully synthesized as a mixture of EIZ- separable geometrical isomers using the same synthetic methodology. The synthesis involved a radical addition and a chemoselective oxidation as key steps. Characterisation was carried out by [1]H NMR, [13]C NMR, IR and HRMS spectroscopies. 2014-11-05T17:41:59Z 2014-11-05T17:41:59Z 2009 Master Thesis Masters MSc http://hdl.handle.net/11427/9281 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Qwebani, Tozama Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents |
| thesis_degree_str | Master's |
| title | Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents |
| title_full | Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents |
| title_fullStr | Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents |
| title_full_unstemmed | Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents |
| title_short | Studies on the synthesis, cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti-cancer agents |
| title_sort | studies on the synthesis cyclodextrin inclusion and biological activity of ajoene analogues as potentially novel anti cancer agents |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/9281 |
| work_keys_str_mv | AT qwebanitozama studiesonthesynthesiscyclodextrininclusionandbiologicalactivityofajoeneanaloguesaspotentiallynovelanticanceragents |