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Alcohol and problem drinking as risk factors for tuberculosis
Includes bibliographical references.
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Public Health and Family Medicine
2014
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| _version_ | 1867614416635166720 |
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| access_status_str | Open Access |
| author | Mkandawire, Tiwonge Jaranthowa |
| author2 | Ehrlich, Rodney |
| author_browse | Ehrlich, Rodney Mkandawire, Tiwonge Jaranthowa |
| author_facet | Ehrlich, Rodney Mkandawire, Tiwonge Jaranthowa |
| author_sort | Mkandawire, Tiwonge Jaranthowa |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9402 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:51:42.095Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Public Health and Family Medicine |
| publisherStr | Department of Public Health and Family Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9402 Alcohol and problem drinking as risk factors for tuberculosis Mkandawire, Tiwonge Jaranthowa Ehrlich, Rodney Public Health and Family Medicine Includes bibliographical references. [Background] Tuberculosis is a major public health concern for South Africa which has one of the highest recorded incidence rates in the world. Previous research [1998 South African Demographic and Health Survey (SADHS)] reported a crude association between alcohol use and tuberculosis. This study aimed to examine evidence for a relationship, and the size thereof, between alcohol consumption and previous tuberculosis in the 2003 SADHS as a means of informing tuberculosis prevention. [ Methods ] This study was a secondary analysis of cross sectional data collected as part of the 2003 SADHS. Tuberculosis lifetime risk was derived from respondent reports of past tuberculosis episodes based on being informed by a healthcare worker. Alcohol consumption, problem drinking as well as selected explanatory variables were generated from similar questions from the adult questionnaire of the SADHS. The CAGE questionnaire was used to measure symptoms of alcohol problems. Logistic regression was used to model the relationship between past tuberculosis and both alcohol consumption and CAGE. [ Results ] Current and previous alcohol consumption were found to be associated with an increase in odds of tuberculosis in both men and women, with odds ratios ranging iii from 1.1 (95% CI 0.9 - 2.5) to 2.8 (95% CI 1.4 - 5.7) after adjusting for potential confounding effects of socioeconomic factors, smoking, nutritional status and age. Having a CAGE score of either 1 to 2 or 3 to 4 was associated with a doubling [OR 2.2 (95% CI 1.0 - 4.8) and quadrupling [OR 4.4 (95% CI 1.4 - 13.4)] in the odds of tuberculosis respectively. [ Discussion ] and conclusion Behavioural and biological mechanisms of effect of alcohol on tuberculosis may explain the findings. Impairment of the immune system, both acute and long term, has been suggested as the mechanism of increased susceptibility to tuberculosis. On the other hand, high risk living conditions and behaviour associated with problem drinking provide potential for increased exposure and susceptibility to tuberculosis infection. The study was able to control for several potentially confounding socioeconomic predictor variables although not HIV infection. The results complement a body of research that has documented the adverse effects of alcohol consumption on health in general and tuberculosis specifically. The findings thus provide more evidence for public health practitioners to tackle the problem of tuberculosis via specific efforts to control alcohol use and abuse, in addition to other methods of tuberculosis control. 2014-11-08T14:32:37Z 2014-11-08T14:32:37Z 2009 Master Thesis Masters MPH http://hdl.handle.net/11427/9402 eng application/pdf Department of Public Health and Family Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Public Health and Family Medicine Mkandawire, Tiwonge Jaranthowa Alcohol and problem drinking as risk factors for tuberculosis |
| thesis_degree_str | Master's |
| title | Alcohol and problem drinking as risk factors for tuberculosis |
| title_full | Alcohol and problem drinking as risk factors for tuberculosis |
| title_fullStr | Alcohol and problem drinking as risk factors for tuberculosis |
| title_full_unstemmed | Alcohol and problem drinking as risk factors for tuberculosis |
| title_short | Alcohol and problem drinking as risk factors for tuberculosis |
| title_sort | alcohol and problem drinking as risk factors for tuberculosis |
| topic | Public Health and Family Medicine |
| url | http://hdl.handle.net/11427/9402 |
| work_keys_str_mv | AT mkandawiretiwongejaranthowa alcoholandproblemdrinkingasriskfactorsfortuberculosis |