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Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2014
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| _version_ | 1867613515109367808 |
|---|---|
| access_status_str | Open Access |
| author | Jackson, Shaun William |
| author2 | Robson, Simon |
| author_browse | Jackson, Shaun William Robson, Simon |
| author_facet | Robson, Simon Jackson, Shaun William |
| author_sort | Jackson, Shaun William |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9506 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:37:22.333Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9506 Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis Jackson, Shaun William Robson, Simon Kirsch, Ralph Medicine Includes bibliographical references. Angiogenesis refers to the growth and maturation of new vessels from pre-existing differentiated blood vessels. Co-ordination of angiogenic responses is crucial for a wide range of physiological and pathological processes. In particular, angiogenesis is hypothesized to facilitate tumour growth and promote metastasis, prompting research into anti-angiogenesis based cancer therapies. CD39/NTPDasel is an ectoenzyme expressed by vascular endothelium that hydrolyses extracellular nucleoside di- and triphosphates to the monophosphate derivatives. As such, this enzyme has a role in modulating endothelial responses to mucleotides that bind specific receptors termed Purinergic-type 2(P2) receptors. Since a number proliferation and migration in vitro, we propose that nucleotide signalling influences the process of angiogenesis in vivo. 2014-11-10T09:04:03Z 2014-11-10T09:04:03Z 2006 Master Thesis Masters MD http://hdl.handle.net/11427/9506 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | Medicine Jackson, Shaun William Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis |
| thesis_degree_str | Master's |
| title | Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis |
| title_full | Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis |
| title_fullStr | Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis |
| title_full_unstemmed | Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis |
| title_short | Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis |
| title_sort | purinergic angiogenesis an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis |
| topic | Medicine |
| url | http://hdl.handle.net/11427/9506 |
| work_keys_str_mv | AT jacksonshaunwilliam purinergicangiogenesisaninvestigationoftheroleofextracellularnucleotidemediatedsignalinginangiogenesis |