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Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Human Biology
2014
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| _version_ | 1867613899015061504 |
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| access_status_str | Open Access |
| author | Womersley, Jacqueline Samantha |
| author2 | Russell, Vivienne A |
| author_browse | Russell, Vivienne A Womersley, Jacqueline Samantha |
| author_facet | Russell, Vivienne A Womersley, Jacqueline Samantha |
| author_sort | Womersley, Jacqueline Samantha |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9530 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:43:28.454Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Human Biology |
| publisherStr | Department of Human Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9530 Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder Womersley, Jacqueline Samantha Russell, Vivienne A Kellaway, Lauriston Stein, Dan J Includes bibliographical references. Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder characterised by age-inappropriate levels of inattention, hyperactivity and impulsivity and is theorised to be caused by dopaminergic dysregulation. Developmental stress interrupts vulnerable periods of neural developmental and has also been found to induce disturbances in dopamine. ADHD and developmental stress are both associated with a higher risk of abusing psychostimulants; drugs that act on the dopaminergic system to elicit a sense of reward. Central to dopamine regulation is the dopamine transporter (DAT), which is responsible for the rapid reuptake of released dopamine and therefore the regulation of extracellul ar dopamine concentration. The aim of this study was to examine the effects of developmental stress and psychostimulant exposure on dopaminergic function, more specifically DAT, in a rat model of ADHD, the spontaneously hypertensive rat (SHR) versus Wistar Kyoto (WKY) and Sprague-Dawley (SD) control strains. 2014-11-11T06:56:13Z 2014-11-11T06:56:13Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/9530 eng application/pdf Department of Human Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Womersley, Jacqueline Samantha Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder |
| thesis_degree_str | Doctoral |
| title | Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder |
| title_full | Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder |
| title_fullStr | Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder |
| title_full_unstemmed | Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder |
| title_short | Methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention-deficit/hyperactivity disorder |
| title_sort | methamphetamine and cocaine effects on dopamine neurons in a rat model of developmental stress and attention deficit hyperactivity disorder |
| url | http://hdl.handle.net/11427/9530 |
| work_keys_str_mv | AT womersleyjacquelinesamantha methamphetamineandcocaineeffectsondopamineneuronsinaratmodelofdevelopmentalstressandattentiondeficithyperactivitydisorder |