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Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents
Includes bibliographical references.
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| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613750849175552 |
|---|---|
| access_status_str | Open Access |
| author | Stringer, Tameryn |
| author2 | Smith, Gregory S |
| author_browse | Smith, Gregory S Stringer, Tameryn |
| author_facet | Smith, Gregory S Stringer, Tameryn |
| author_sort | Stringer, Tameryn |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9542 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:41:07.152Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9542 Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents Stringer, Tameryn Smith, Gregory S Egan, Timothy J Includes bibliographical references. Malaria remains a major global health problem and to date, hundreds of thousands of people die as a result of this disease every year. Malaria has been able to adapt and rebound despite various efforts made to combat the disease. The decrease in efficacy of many front-line drugs against malaria, due to increased resistance, prompts investigation into obtaining effective compounds that are able to overcome this resistance. This study investigated the synthesis, characterisation and biological evaluation of new quinoline as well as non-quinoline based compounds. Selected Rh(I) metal complexes thereof were also studied. The compounds were screened for antiplasmodial activity, in addition, their activity against WHCO1 oesophageal cancer cells and the parasite, Trichomonas vaginalis (T vaginalis) was also evaluated. 2014-11-11T07:02:32Z 2014-11-11T07:02:32Z 2014 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/9542 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Stringer, Tameryn Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents |
| thesis_degree_str | Doctoral |
| title | Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents |
| title_full | Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents |
| title_fullStr | Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents |
| title_full_unstemmed | Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents |
| title_short | Development of quinoline and non-quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents |
| title_sort | development of quinoline and non quinoline based organometallic complexes and their ligands conjugated to polyamine scaffolds as pharmacological agents |
| url | http://hdl.handle.net/11427/9542 |
| work_keys_str_mv | AT stringertameryn developmentofquinolineandnonquinolinebasedorganometalliccomplexesandtheirligandsconjugatedtopolyaminescaffoldsaspharmacologicalagents |