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Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis

Includes bibliographical references (leaves 116-122).

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Main Author: Kuter, David
Other Authors: Egan, Timothy J
Format: Thesis
Language:English
Published: Department of Chemistry 2014
Subjects:
Chemistry
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access_status_str Open Access
author Kuter, David
author2 Egan, Timothy J
author_browse Egan, Timothy J
Kuter, David
author_facet Egan, Timothy J
Kuter, David
author_sort Kuter, David
collection Thesis
description Includes bibliographical references (leaves 116-122).
format Thesis
id oai:open.uct.ac.za:11427/9562
institution University of Cape Town (South Africa)
language eng
last_indexed 2026-06-10T12:34:27.383Z
license_str Not specified — see source repository
provenance_str_mv Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository
publishDate 2014
publishDateRange 2014
publishDateSort 2014
publisher Department of Chemistry
publisherStr Department of Chemistry
record_format dspace
source_str UCTD — University of Cape Town Open Access Repository
spelling oai:open.uct.ac.za:11427/9562 Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis Kuter, David Egan, Timothy J Chibale, Kelly Chemistry Includes bibliographical references (leaves 116-122). Investigation of coordination and π-stacking interactions with ferriprotoporphyrin IX (Fe(III)PPIX) using a fragment approach was undertaken in order to propose and synthesise novel compounds which followed a hypothesised mechanism of action to inhibit β-haematin formation. Coordination of a series of pyridines, imidazoles, amines and phenolates with Fe(III)PPIX, and n-stacking interactions of these compounds with protoporphyrin IX (PPIX) and Fe(III)PPIX were measured in 40% (v/v) aq. DMSO by spectrophotometric titration. 2014-11-11T12:58:14Z 2014-11-11T12:58:14Z 2009 Master Thesis Masters MSc http://hdl.handle.net/11427/9562 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town
spellingShingle Chemistry
Kuter, David
Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
thesis_degree_str Master's
title Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_full Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_fullStr Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_full_unstemmed Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_short Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
title_sort towards a fragment approach to haemozoin inhibiting antimalarials exploration of coordination and π stacking interactions with fe iii ppix by spectroscopy and synthesis
topic Chemistry
url http://hdl.handle.net/11427/9562
work_keys_str_mv AT kuterdavid towardsafragmentapproachtohaemozoininhibitingantimalarialsexplorationofcoordinationandpstackinginteractionswithfeiiippixbyspectroscopyandsynthesis

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