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Physicochemical study of inclusion of drug molecules in cyclodextrins
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613734002753536 |
|---|---|
| access_status_str | Open Access |
| author | Dodds, Devric Reginald |
| author2 | Caira, Mino R |
| author_browse | Caira, Mino R Dodds, Devric Reginald |
| author_facet | Caira, Mino R Dodds, Devric Reginald |
| author_sort | Dodds, Devric Reginald |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/9721 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:40:51.086Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/9721 Physicochemical study of inclusion of drug molecules in cyclodextrins Dodds, Devric Reginald Caira, Mino R Chemistry Includes bibliographical references. Inclusion of drug molecules in cyclodextrins can significantly improve various aspects of their performance and has resulted in the use of cyclodextrins (CDs) for a wide variety of pharmaceutical applications. Consequently, the cyclodextrin inclusion of drugs has received great interest in the pharmaceutical and chemical fields. For this study the inclusion of nine pharmaceutical drugs with CDs was investigated in the solid state. The objectives of the study were i.) the preparation, ii.) determination of the chemical composition, iii.) analysis of thermal behaviour and iv.) investigation of the solid state features of the complexes. Ultraviolet spectrophotometry, elemental analysis and thermogravimetric analysis were the principal techniques used for determination of composition. Hot stage microscopy, differential scanning calorimetry and thermogravimetric analysis were the principal techniques used for the analysis of thermal behaviour. Single crystal x-ray diffraction and x-ray powder diffraction were the principal techniques used for investigation of structural features. This thesis reports the preparation by crystallisation from solution of eight beta cyclodextrin (β-CD) and four gamma cyclodextrin (γ-CD) inclusion complexes with selected drugs as guests, as well as the determination of their chemical compositions and analysis of their thermal behaviours. Investigation of the structural features of these complexes includes the determination of the crystal structures of five β-CD complexes and one γ-CD complex. The preparation of hydnoxypropyl-β-CD complexes by kneading and co-grinding is also reported. 2014-11-18T18:28:07Z 2014-11-18T18:28:07Z 1999 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/9721 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Dodds, Devric Reginald Physicochemical study of inclusion of drug molecules in cyclodextrins |
| thesis_degree_str | Doctoral |
| title | Physicochemical study of inclusion of drug molecules in cyclodextrins |
| title_full | Physicochemical study of inclusion of drug molecules in cyclodextrins |
| title_fullStr | Physicochemical study of inclusion of drug molecules in cyclodextrins |
| title_full_unstemmed | Physicochemical study of inclusion of drug molecules in cyclodextrins |
| title_short | Physicochemical study of inclusion of drug molecules in cyclodextrins |
| title_sort | physicochemical study of inclusion of drug molecules in cyclodextrins |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/9721 |
| work_keys_str_mv | AT doddsdevricreginald physicochemicalstudyofinclusionofdrugmoleculesincyclodextrins |