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Developmental signaling genes in ameloblastoma
Context: This study investigated the presence or absence of β-catenin and Patched1 (PTCH1) genes involved in the developmental pathway in ameloblastoma, in order to clarify the genetic etiology of this tumor. Aim: The aim of this study was to investigate whether PTCH1 and β-catenin genes are involve...
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2015
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/1137 | ||
| 042 | |a dc | ||
| 720 | |a Onyegbula, K. |e author | ||
| 720 | |a Onile, O. S. |e author | ||
| 720 | |a Okoje, V. N. |e author | ||
| 720 | |a Anumudu, C. I. |e author | ||
| 260 | |c 2015 | ||
| 520 | |a Context: This study investigated the presence or absence of β-catenin and Patched1 (PTCH1) genes involved in the developmental pathway in ameloblastoma, in order to clarify the genetic etiology of this tumor. Aim: The aim of this study was to investigate whether PTCH1 and β-catenin genes are involved in the development of ameloblastoma. Subjects and Methods: Archived formalin-fixed paraffin-embedded specimens of 89 ameloblastoma cases from the year 2000 to 2010 were genotyped by polymerase chain reaction (PCR). Results: A total of 21 (23.6%) of the 89 ameloblastoma cases were positive for β-catenin gene, where 14/21 (66.7%) cases were mandibular ameloblastoma. Plexiform 5/21 (23.8%) and cystic 5/21 (23.8%) ameloblastoma were the most regular histological type positive for β-catenin. However, β-catenin positive was more in the feminine gender (11/19, 57.9%) than the masculine (8/19, 42.1%). Only one case was positive for PTCH1 gene and this was histologically a mandibular site and plexiform-type ameloblastoma. Conclusions: This study suggested that β-catenin and PTCH1 genes may play an important role in the pathogenesis of ameloblastoma. | ||
| 024 | 8 | |a 1965-0817 ||1965-0825 | |
| 024 | 8 | |a Journal of African Cancer 7, pp. 16-21 | |
| 024 | 8 | |a ui_art_onyegbula_development_2015 | |
| 024 | 8 | |a http://ir.library.ui.edu.ng/handle/123456789/1137 | |
| 245 | 0 | 0 | |a Developmental signaling genes in ameloblastoma |