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Influence of kolaviron and vitamin E on ethylene glycol monoethyl ether-induced haematotoxicity and renal apoptosis in rats
The present study investigated the protective effects of kolaviron, a biflavonoid from the seed of Garcinia kola, and vitamin E on ethylene glycol monoethyl ether (EGEE)-induced haematotoxicity and renal apoptosis in male rats. EGEE was administered at a dose of 200 mg kg_1 alone or simultaneously a...
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2013
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/11968 | ||
| 042 | |a dc | ||
| 720 | |a Adedara, I. A. |e author | ||
| 720 | |a Farombi, E. O. |e author | ||
| 260 | |c 2013 | ||
| 520 | |a The present study investigated the protective effects of kolaviron, a biflavonoid from the seed of Garcinia kola, and vitamin E on ethylene glycol monoethyl ether (EGEE)-induced haematotoxicity and renal apoptosis in male rats. EGEE was administered at a dose of 200 mg kg_1 alone or simultaneously administered with kolaviron (100 and 200 mg kg_1) and vitamin E (50 mg kg_1) for 14 days. Results of haematological examination showed that white blood cells, platelets, neutrophils and mean corpuscular haemoglobin concentration were significantly lower, whereas lymphocytes were increased in EGEE-exposed rats compared with those in the control. Administration of EGEE caused a significant decrease in the superoxide dismutase and catalase activities as well as in the glutathione level but significantly increased glutathione S-transferase activity and levels of hydrogen peroxide and lipid peroxidation in kidneys of rats compared with those in the control. Also, EGEE-treated rats showed significant elevation in the serum urea and creatinine with marked increase in the frequency of terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay-positive apoptotic cells in the tubular epithelial cells in comparison with the control. Co-administration with kolaviron or vitamin E exhibited chemoprotective effects against EGEE-mediated haematotoxicity, augmented renal antioxidant status and prevented the induction of renal apoptosis. | ||
| 024 | 8 | |a 1099-0844 | |
| 024 | 8 | |a ui_art_adedara_influence_2014 | |
| 024 | 8 | |a Cell Biochemistry & Function 32, pp. 31–38. | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/11968 | |
| 653 | |a ethylene glycol monoethyl ether (EGEE) | ||
| 653 | |a nephrotoxicity | ||
| 653 | |a oxidative stress | ||
| 653 | |a apoptosis | ||
| 653 | |a rat | ||
| 245 | 0 | 0 | |a Influence of kolaviron and vitamin E on ethylene glycol monoethyl ether-induced haematotoxicity and renal apoptosis in rats |