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Redox status of the testes and sperm of rats following exposure to 2,5-hexanedione
Objectives: Exposure to 2, 5-hexanedione (2, 5-HD) is well known to be associated with reproductive dysfunctions in both humans and animals. However, the role of oxidative stress in 2, 5-HD-induced toxicity in testes and sperm has not yet been studied. Methodology: The present study investigated the...
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2016
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/11997 | ||
| 042 | |a dc | ||
| 720 | |a Adedara, I. A. || || || || || |e author | ||
| 720 | |a Abolaji, A. O. |e author | ||
| 720 | |a Odion, B. E. |e author | ||
| 720 | |a Omoloja, A. A. |e author | ||
| 720 | |a Okwudi, I. J. |e author | ||
| 720 | |a Farombi, E. O. |e author | ||
| 260 | |c 2016 | ||
| 520 | |a Objectives: Exposure to 2, 5-hexanedione (2, 5-HD) is well known to be associated with reproductive dysfunctions in both humans and animals. However, the role of oxidative stress in 2, 5-HD-induced toxicity in testes and sperm has not yet been studied. Methodology: The present study investigated the influence of 2, 5-HD on antioxidant systems in the testes and epididymal sperm of rats following exposure to 0, 0.25, 0.5, and 1% 2, 5-HD in drinking water for 21 consecutive days. Results: Administration of 0.5% 2, 5-HD significantly (P < 0.05) decreased epididymis weight, whereas 1% 2, 5-HD-treated rats showed significantly decreased body weight, testis, and epididymis weights compared with the control group. Exposure to 2, 5-HD caused a significant dose-dependent increase in the activities of superoxide dismutase, catalase, and glutathione peroxidase in both testes and sperm compared with the control group. Moreover, 2, 5-HD-exposed rats showed significant decrease in glutathione-S-transferase activity and glutathione level with concomitant significant elevation in the levels of hydrogen peroxide and malondialdehyde in both testes and sperm. Testicular and epididymal atrophy with significant, dose-dependent, decrease in epididymal sperm number, sperm motility, and viability were observed in 2, 5-HD-treated rats. Conclusion: 2,5-HD exposure impaired testicular function and sperm characteristics by disruption of the antioxidant systems and consequently, increased oxidative stress in the treated rats. | ||
| 024 | 8 | |a 1743-2928 | |
| 024 | 8 | |a ui_art_adedara_redox_2016 | |
| 024 | 8 | |a Redox Report 21(6), pp. 239-247 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/11997 | |
| 653 | |a 2 5-Hexanedione | ||
| 653 | |a Antioxidant systems | ||
| 653 | |a Oxidative stress | ||
| 653 | |a Testes | ||
| 653 | |a Sperm | ||
| 653 | |a Rats | ||
| 245 | 0 | 0 | |a Redox status of the testes and sperm of rats following exposure to 2,5-hexanedione |