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6-Gingerol-rich fraction prevents disruption of histomorphometry and marker enzymes of testicular function in carbendazim-treated rats
Previous investigations demonstrated that 6-gingerol-rich fraction (6-GRF) prevented testicular toxicity via inhibition of oxidative stress and endocrine disruption in CBZ-treated rats. The influence of 6-GRF on alterations in histomorphometry and marker enzymes of testicular function in CBZ-treated...
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2017
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12006 | ||
| 042 | |a dc | ||
| 720 | |a Salihu, M. |e author | ||
| 720 | |a Ajayi, B. O. |e author | ||
| 720 | |a Adedara, I. A. |e author | ||
| 720 | |a Farombi, E. O. |e author | ||
| 260 | |c 2017 | ||
| 520 | |a Previous investigations demonstrated that 6-gingerol-rich fraction (6-GRF) prevented testicular toxicity via inhibition of oxidative stress and endocrine disruption in CBZ-treated rats. The influence of 6-GRF on alterations in histomorphometry and marker enzymes of testicular function in CBZ-treated rats which hitherto has not been reported was investigated in this study. The animals were orally administered either CBZ (50 mg/kg) alone or in combination with 6-GRF (50, 100 and 200 mg/kg) for 14 consecutive days. Histomorphormetric analysis demonstrated that 6-GRF significantly prevented CBZ-mediated increase in the organo-somatic index of the testes and seminiferous tubular diameter as well as the reduction in epithelium height and tubular length of testes in the rats. Similarly, 6-GRF ameliorated CBZ-induced disruption in the epithelium height as well as in the proportion of tubule and interstitium of the epididymis the treated rats. Furthermore, 6-GRF prevented CBZ-mediated increase in testicular acid phosphatase activity and the decrease in testicular alkaline phosphatase, aminotransferases, glucose-6- phosphate dehydrogenase and lactate dehydrogenase activities. Moreover, 6-GRF ameliorated CBZ-induced reduction in the testicular and epididymal sperm count and sperm motility in the treated rats. Conclusively, 6-GRF enhances key functional enzymes involve in spermatogenesis and maintains histo-architecture of testes and epididymis in CBZ-treated rats. | ||
| 024 | 8 | |a 1439-0272 | |
| 024 | 8 | |a ui_art_salihu_6-gingerol_2017 | |
| 024 | 8 | |a Andrologia 49, pp. 1-11 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12006 | |
| 653 | |a 6-gingerol-rich fraction | ||
| 653 | |a carbendazim | ||
| 653 | |a histomorphometry | ||
| 653 | |a marker enzymes | ||
| 653 | |a reproductive toxicity | ||
| 245 | 0 | 0 | |a 6-Gingerol-rich fraction prevents disruption of histomorphometry and marker enzymes of testicular function in carbendazim-treated rats |