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Ethanol exacerbates manganese - induced functional alterations along the hypothalamic-pituitary-gonadal axis of male rats
Manganese (Mn) exposure has been reported to induce reproductive dysfunction in animal and humans. Studies have shown that a large percentage of adolescent and adult populations tend to consume alcohol in a binge pattern. However, there is no information on the influence of alcohol on Mn - induced f...
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2018
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12018 | ||
| 042 | |a dc | ||
| 720 | |a Nkpaaa, K. W. |e author | ||
| 720 | |a Amadi, B. A. |e author | ||
| 720 | |a Adedara, I. A |e author | ||
| 720 | |a Wegwu, M. O. |e author | ||
| 720 | |a Farombi, E. O. |e author | ||
| 260 | |c 2018 | ||
| 520 | |a Manganese (Mn) exposure has been reported to induce reproductive dysfunction in animal and humans. Studies have shown that a large percentage of adolescent and adult populations tend to consume alcohol in a binge pattern. However, there is no information on the influence of alcohol on Mn - induced functional alteration along the hypothalamic - pituitary - gonadal axis. This study aimed to evaluate the influence of ethanol (EtOH) on Mn - induced functional alteration along the hypothalamic - pituitary - gonadal axis. Rats were exposed to Mn alone at 30 mg/kg body weight or co-expose with EtOH at 1.25 and 5 g/kg body weight for 35 consecutive days. Results showed that EtOH exposure significantly (p < 0.05) exacerbated Mn - induced decrease in anti- oxidant enzymes activities, glutathione level and increased oxidative stress biomarkers in the hypothalamus, testes an epididymis of the exposed rats. Moreover, induction of inflammation was associated with disruption of histo-architecture of the hypothalamus, testes and epididymis of rats treated with Mn alone, EtOH alone or in combination. Furthermore, EtOH significantly exacerbated Mn - induced diminution in reproductive hormones and marker enzymes of testicular functions coupled with decreased sperm quantity and quality. Taken together, EtOH exacerbates Mn - induced functional alteration along the hypothalamic - pituitary - gonadal axis in rats via mechanisms involving induction of oxidative/nitrosative stress, lipid peroxidation and inflammation in rats. | ||
| 024 | 8 | |a 1872-7972 | |
| 024 | 8 | |a ui_art_nkpaa_ethanol_2018 | |
| 024 | 8 | |a Neuroscience Letters 684, pp. 47-54 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12018 | |
| 653 | |a Manganese | ||
| 653 | |a Ethanol | ||
| 653 | |a HPG axis | ||
| 653 | |a Oxidative stress | ||
| 653 | |a Inflammation | ||
| 653 | |a Hypothalamus | ||
| 245 | 0 | 0 | |a Ethanol exacerbates manganese - induced functional alterations along the hypothalamic-pituitary-gonadal axis of male rats |