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Gallic acid enhances reproductive function by modulating oxidoinflammatory and apoptosis mediators in rats exposed to aflatoxin-B1
Aflatoxin B1 (AFB1) is reported to elicit adverse reproductive outcomes in animals. Gallic acid (GA) is known to exhibit antioxidant and inflammatory bioactivities. The impact of GA on AFB1-facilitated reproductive dysfunction is nonexistent in literature. This investigation elucidated GA protective...
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| Format: | Article |
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2020
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12042 | ||
| 042 | |a dc | ||
| 720 | |a Owumi, S. E. |e author | ||
| 720 | |a Adedara, I. A. |e author | ||
| 720 | |a Akomolafe, A. P. |e author | ||
| 720 | |a Farombi, E. O. |e author | ||
| 720 | |a Oyelere, A. K. |e author | ||
| 260 | |c 2020 | ||
| 520 | |a Aflatoxin B1 (AFB1) is reported to elicit adverse reproductive outcomes in animals. Gallic acid (GA) is known to exhibit antioxidant and inflammatory bioactivities. The impact of GA on AFB1-facilitated reproductive dysfunction is nonexistent in literature. This investigation elucidated GA protective effect on AFB1-induced reproductive toxicities in rats, exposed for 28 consecutive days to AFB1 (75 mg/kg), or co-treated with GA (20 or 40 mg/kg) body weight. AFB1 significantly (p<0.05) reduced testicular function biomarkers, serum hormonal levels, and functional sperm characteristics in experimental animals. GA abated AFB1-induced increases (p<0.05) in lipid peroxidation and reactive oxygen and nitrogen species, suppressed myeloperoxidase, interleukin-1b, nitric oxide, and tumor necrosis factor-a levels—inflammatory biomarkers—in testes, epididymis, and hypothalamus. Furthermore, GA improved antioxidant defenses and alleviated reduction in interleukin-10, caspase-3 activation, and histological variations in epididymis, testes, and hypothalamus of rats dosed with AFB1. Conclusively, GA enhanced reproductive function in AFB1-exposed rats by modulating inflammatory, oxidative stress, and apoptosis mediators. | ||
| 024 | 8 | |a 1535-3702 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12042 | |
| 653 | |a Aflatoxin B1 | ||
| 653 | |a gallic acid | ||
| 653 | |a reproductive deficits | ||
| 653 | |a oxidative stress | ||
| 653 | |a inflammation | ||
| 653 | |a caspase-3 | ||
| 245 | 0 | 0 | |a Gallic acid enhances reproductive function by modulating oxidoinflammatory and apoptosis mediators in rats exposed to aflatoxin-B1 |