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6-Gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer in mice
Colorectal cancer (CRC) has been linked to dietary consumption of benzo[a]pyrene (B[a]P). 6-Gingerol (6-G), a component of ginger has been reported to possess anti-inflammatory and antioxidant activities, but little is known regarding the mechanism of 6-G in CRC chemoprevention. We therefore investi...
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2020
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12043 | ||
| 042 | |a dc | ||
| 720 | |a Farombi, E. O. || || |e author | ||
| 720 | |a Ajayi, B. O. |e author | ||
| 720 | |a Adedara, I. A. |e author | ||
| 260 | |c 2020 | ||
| 520 | |a Colorectal cancer (CRC) has been linked to dietary consumption of benzo[a]pyrene (B[a]P). 6-Gingerol (6-G), a component of ginger has been reported to possess anti-inflammatory and antioxidant activities, but little is known regarding the mechanism of 6-G in CRC chemoprevention. We therefore investigated the effect of 6-G on B[a]P. and dextran sulphate sodium (DSS) induced CRC in mice. Mice in Group I and Group II received corn oil and 6-G orally at 2 ml/kg and 100 mg/kg, respectively for 126 days. Group III were administered 125 mg/kg of B [a]P for 5 days followed by 3 cycles of 4% dextran sulphate sodium (DSS). Group IV received 6-G for 7 days followed by co-administration with 125 mg/kg of B[a]P. for 5 days and 3 cycles of 4% DSS. Tumor formation was reduced and expression of Ki-67, WNT3a, DVL-2 and p-catenin following 6-G exposure. Also, 6-G increases expression of APC, P53, TUNEL positive nuclei and subsequently decreased the expression of TNF-a, IL-1p, INOS, COX-2 and cyclin D1. 6-G inhibited angiogenesis by decreasing the concentration of VEGF, Angiopoietin- 1, FGF and GDF-15 in the colon of B[a]P. and DSS exposed mice. Overall, 6-G attenuated B[a]P and DSS-induced CRC in mice via anti-inflammatory, anti-proliferative and apoptotic mechanisms. | ||
| 024 | 8 | |a 0278-6915 | |
| 024 | 8 | |a ui_art_farombi_6-gingerol_2020 | |
| 024 | 8 | |a Food and Chemical Toxicology 142 (111483) | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12043 | |
| 653 | |a Colorectal cancer | ||
| 653 | |a 6-Gingerol | ||
| 653 | |a Wnt/pCatenin signaling | ||
| 653 | |a Inflammation | ||
| 653 | |a Cell cycle | ||
| 653 | |a Angiogenesis | ||
| 245 | 0 | 0 | |a 6-Gingerol delays tumorigenesis in benzo[a]pyrene and dextran sulphate sodium-induced colorectal cancer in mice |