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Indole-3-propionic acid mitigates chlorpyrifos-mediated neurotoxicity by modulating cholinergic and redox-regulatory systems, inflammatory stress, apoptotic responses and DNA damage in rats
This study probed the neuroprotective influence of indole-3-propionic acid (IPA) in rats exposed to chlorpyrifos (CPF) alone at 5 mg/kg body weight or co-administered with IPA at 12.5 and 25 mg/kg for 14 days. Behavioral data indicated that IPA significantly (p < 0.05) abated CPF-mediated anxiogenic...
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| Format: | Article |
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2022
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12070 | ||
| 042 | |a dc | ||
| 720 | |a Owumi, S. E. |e author | ||
| 720 | |a Adedara, I. A. |e author | ||
| 720 | |a Oyelere, A. K. |e author | ||
| 260 | |c 2022 | ||
| 520 | |a This study probed the neuroprotective influence of indole-3-propionic acid (IPA) in rats exposed to chlorpyrifos (CPF) alone at 5 mg/kg body weight or co-administered with IPA at 12.5 and 25 mg/kg for 14 days. Behavioral data indicated that IPA significantly (p < 0.05) abated CPF-mediated anxiogenic-like behaviors with concomitant improvement in the locomotor and exploratory behaviors as substantiated by track plots and heat maps data. Also, IPA mitigated CPF-mediated diminution in cholinergic and antioxidant defense systems whereas it mark- edly improved thioredoxin level and thioredoxin reductase activity in cerebral and cerebellar tissues of the animals. Co-administration of IPA significantly enhanced anti-inflammatory cytokine, interleukin-10 but sup- pressed oxidative and inflammatory stress, caspase-9 and caspase-3 activation with concomitant reduction in 8- hydroxy-2'-deoxyguanosine (8-OHdG) level and histological damage. Collectively, IPA-mediated neuro- protection involves modulation of cholinergic and redox-regulatory systems, inflammatory stress, apoptotic re- sponses and DNA damage in cerebrum and cerebellum of rats. | ||
| 024 | 8 | |a 1382-6689 | |
| 024 | 8 | |a ui_art_owumi_indole_2022 | |
| 024 | 8 | |a Environmental Toxicology and Pharmacology 89 (103786) | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12070 | |
| 653 | |a Chlorpyrifos | ||
| 653 | |a Indole-3-propionic acid | ||
| 653 | |a Acetylcholinesterase | ||
| 653 | |a Redox-regulatory systems | ||
| 653 | |a 8-hydroxy-2'-deoxyguanosine | ||
| 245 | 0 | 0 | |a Indole-3-propionic acid mitigates chlorpyrifos-mediated neurotoxicity by modulating cholinergic and redox-regulatory systems, inflammatory stress, apoptotic responses and DNA damage in rats |