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Zebrafish as a potential non-traditional model organism in translational bipolar disorder research: Genetic and behavioral insights
Bipolar disorder (BD) is a severe and debilitating illness that affects 1-2% of the population worldwide. BD is characterized by recurrent and extreme mood swings, including mania/hypomania and depression. Animal experimental models have been used to elucidate the mechanisms underlying BD and differ...
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| Format: | Article |
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2022
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12073 | ||
| 042 | |a dc | ||
| 720 | |a Canzian, J. |e author | ||
| 720 | |a Goncalves, F. L. S. |e author | ||
| 720 | |a Muller, T. E. |e author | ||
| 720 | |a Fransescon, F. |e author | ||
| 720 | |a Santos, L. W. |e author | ||
| 720 | |a Adedara, I. A. |e author | ||
| 720 | |a Rosemberg, D. B. |e author | ||
| 260 | |c 2022 | ||
| 520 | |a Bipolar disorder (BD) is a severe and debilitating illness that affects 1-2% of the population worldwide. BD is characterized by recurrent and extreme mood swings, including mania/hypomania and depression. Animal experimental models have been used to elucidate the mechanisms underlying BD and different strategies have been proposed to assess BD-like symptoms. The zebrafish (Danio rerio) has been considered a suitable vertebrate system for modeling BD-like responses, due to the genetic tractability, molecular/physiological conservation, and well-characterized behavioral responses. In this review, we discuss how zebrafish-based models can be suc- cessfully used to understand molecular, biochemical, and behavioral alterations paralleling those found in BD. We also outline some advantages and limitations of this aquatic species to examine BD-like phenotypes in translational neurobehavioral research. Overall, we reinforce the use of zebrafish as a promising tool to investigate the neural basis associated with BD-like behaviors, which may foster the discovery of novel pharmaco- logical therapies. | ||
| 024 | 8 | |a 0149-7634 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12073 | |
| 653 | |a Bipolar disorder | ||
| 653 | |a Zebrafish | ||
| 653 | |a Behavioral responses | ||
| 653 | |a Genetic mechanisms | ||
| 653 | |a Neurochemistry | ||
| 653 | |a Monoaminergic system | ||
| 245 | 0 | 0 | |a Zebrafish as a potential non-traditional model organism in translational bipolar disorder research: Genetic and behavioral insights |