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Spectrophotometric determination of Olanzepine following condensation reaction with p-dimethylaminobenzaldehyde
A new, simple, cost-effective spectrophotometric method was developed for the determination of olanzapine in pharmaceuticals. The new method is based on formation of a yellow condensation product with p-dimethylaminobenzaldehyde, followed by measurement of absorbance at 410 nm. The reaction variable...
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2014
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12085 | ||
| 042 | |a dc | ||
| 720 | |a Adegoke, O. A. |e author | ||
| 720 | |a Thomas, O. E. |e author | ||
| 720 | |a Makanjuola, D. M. |e author | ||
| 720 | |a Adewole, O. O. |e author | ||
| 260 | |c 2014 | ||
| 520 | |a A new, simple, cost-effective spectrophotometric method was developed for the determination of olanzapine in pharmaceuticals. The new method is based on formation of a yellow condensation product with p-dimethylaminobenzaldehyde, followed by measurement of absorbance at 410 nm. The reaction variables were optimized at 500C and 10 min. The reaction occurred at a stoichiometric ratio of 1:1. Absorbance was found to increase linearly with the concentration of the drug and formed the basis for quantification. The calibration graph was linear between 5 and 160 µgmL−1, and the correlation coefficient was 0.999. The apparent molar absorptivity was 0.6 ×103 L mol−1 cm−1, and the calculated Sandell sensitivity was 49.50 ng cm−2. The limits of detection and quantification were 6.6 and 20 µg mL−1, respectively. The method was validated in terms of accuracy, precision and reproducibility. The overall recovery was 98.4–101.5%, with an error of less than 1.7%. The proposed method was applied to the analysis of olanzapine in pure and dosage form and found to be of equivalent accuracy and precision to the official Indian Pharmacopoeia high-performance liquid chromatography method. There was no interference from commonly used excipients. The method could readily be adapted for use in developing countries where sophisticated equipment is not available. | ||
| 024 | 8 | |a 1658-3655 | |
| 024 | 8 | |a ui_art_adegoke_spectrophotometric_2014 | |
| 024 | 8 | |a Journal of Taibah University for Science 8(3), pp. 248-257 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12085 | |
| 653 | |a Olanzapine | ||
| 653 | |a p-Dimethylaminobenzaldehyde | ||
| 653 | |a Condensation | ||
| 653 | |a Spectrophotometric determination | ||
| 245 | 0 | 0 | |a Spectrophotometric determination of Olanzepine following condensation reaction with p-dimethylaminobenzaldehyde |