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Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria
Background: Children and adolescents with end-stage renal disease (ESRD) in sub-Saharan Africa may have the worst outcomes globally. Barriers to management include late presentation, poor socioeconomic conditions, absence of medical insurance, limited diagnostic facilities and non-availability of ch...
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2014
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12177 | ||
| 042 | |a dc | ||
| 720 | |a Asinobi, A. O. |e author | ||
| 720 | |a Ademola, A. D. |e author | ||
| 720 | |a Ogunkunle, O. O. |e author | ||
| 720 | |a Mott S. A. |e author | ||
| 260 | |c 2014 | ||
| 520 | |a Background: Children and adolescents with end-stage renal disease (ESRD) in sub-Saharan Africa may have the worst outcomes globally. Barriers to management include late presentation, poor socioeconomic conditions, absence of medical insurance, limited diagnostic facilities and non-availability of chronic renal replacement therapy (RRT). Our study was to determine the incidence, aetiology, management and outcomes of paediatric ESRD in a tertiary hospital in Nigeria. Methods: A retrospective case review of paediatric ESRD at the University College Hospital Ibadan, Nigeria, over 8 years, from January 2005 to December 2012. Results: 53 patients (56.6% male), median age 11 (inter quartile range 8.5-12) years were studied. Mean annual incidence of ESRD in Ibadan for children aged 14 years and below was 4 per million age related population (PMARP) while for those aged 5-14 years it was 6.0 PMARP. Glomerulonephritis was the cause in 41 (77.4%) patients amongst whom, 29 had chronic glomerulonephritis and 12 had nephrotic syndrome. Congenital anomalies of the kidneys and urinary tract (CAKUT) accounted for 11 (21.2%) cases, posterior urethral valves being the most common. Acute haemodialysis, acute peritoneal dialysis or a combination of these were performed in 33 (62.3%), 6 (11.3%) and 4 (7.5%) patients respectively. Median survival was 47 days and in-hospital mortality was 59%. Conclusions: Incidence of paediatric ESRD in Ibadan is higher than previous reports from sub-Saharan Africa. Glomerulonephritis, and then CAKUT are the most common causes. Mortality is high, primarily due to lack of resources. Preventive nephrology and chronic RRT programmes are urgently needed. | ||
| 024 | 8 | |a 1440-1797 | |
| 024 | 8 | |a ui_art_asinobi_paediatric_2014 | |
| 024 | 8 | |a Nephrology, 15(25) | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12177 | |
| 653 | |a End-stage renal disease | ||
| 653 | |a Children | ||
| 653 | |a Chronic kidney disease | ||
| 653 | |a Glomerulonephritis | ||
| 653 | |a Congenital anomalies of the kidneys and urinary tract | ||
| 653 | |a Nephrotic syndrome | ||
| 653 | |a Nigeria | ||
| 245 | 0 | 0 | |a Paediatric end-stage renal disease in a tertiary hospital in South West Nigeria |