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Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome
Introduction: Available data on plasma homocysteine level in patients with nephrotic syndrome (NS) are controversial with increased, decreased and unchanged values reported. Therefore, plasma homocysteine and serum B vitamins in Nigerian children with NS were assessed in this study Methods: Fasting...
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2014
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12178 | ||
| 042 | |a dc | ||
| 720 | |a Orimadegun, B. E. |e author | ||
| 720 | |a Orimadegun, A. E. |e author | ||
| 720 | |a Ademola, A. D. |e author | ||
| 720 | |a Agbedana, E. O. |e author | ||
| 260 | |c 2014 | ||
| 520 | |a Introduction: Available data on plasma homocysteine level in patients with nephrotic syndrome (NS) are controversial with increased, decreased and unchanged values reported. Therefore, plasma homocysteine and serum B vitamins in Nigerian children with NS were assessed in this study Methods: Fasting blood samples were analysed for plasma homocysteine, serum folate and B vitamins in 42 children with NS and 42 age and sex-matched healthy controls in this case control study. Data were compared between NS and control using t test and Chi square. Relationships were tested with regression analysis with p set at 0.05. Results: Prevalence of hyperhomocysteinaemia, low folate and cyanocobalamin in NS was 57.1%, 14.3% and 9.5% respectively. The mean homocysteine level was significantly higher in NS than control (11.3±2.6μmol/L versus 5.5±2.3μmol/L). Also, NS had lower folate and cyanocobalamin than control: 9.1±3.9ng/mL versus 11.2±3.1ng/dL and 268.5±95.7pg/mL versus 316±117.2pg/mL respectively. Weak but significant correlation between homocysteine and serum albumin (r = 0.347), folate (r = -0.607) and vitamin B12 (r = -0.185) were found in the NS group. Significant relationship was also found between homocysteine and vitamin B12 (ß = -0.64, 95% CI = -1.20, -0.08) after controlling for folate and vitamin B6 levels. Conclusion: Clinically important hyperhomocysteinaemia and low B vitamins occur in Nigerian children with nephrotic syndrome. This data suggest that potential usefulness of folate and vitamin B supplementation for reducing high homocysteine levels in nephrotic syndrome need to be further investigated | ||
| 024 | 8 | |a 1937- 8688 | |
| 024 | 8 | |a ui_art_orimadegun_plasma_2014 | |
| 024 | 8 | |a The Pan African Medical Journal, 18(107) | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12178 | |
| 653 | |a Nephrotic syndrome | ||
| 653 | |a homocysteine | ||
| 653 | |a cardiovascular risk | ||
| 653 | |a vitamins | ||
| 653 | |a folate | ||
| 653 | |a children | ||
| 245 | 0 | 0 | |a Plasma homocysteine and B vitamins levels in Nigerian children with nephrotic syndrome |