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Acute kidney injury among paediatric emergency room admissions in a tertiary hospital in South West Nigeria: a cohort study
Background. Epidemiological data on paediatric acute kidney injury (AKI) in sub-Saharan Africa are limited and largely retrospective. We performed a prospective study of AKI among patients admitted through the emergency room. Methods. Children admitted to the post-neonatal emergency room of the Uni...
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2019
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12206 | ||
| 042 | |a dc | ||
| 720 | |a Ademola, A. D. |e author | ||
| 720 | |a Asinobi, A. O. |e author | ||
| 720 | |a Ekpe-Adewuyi, E. |e author | ||
| 720 | |a Ayede, A. I. |e author | ||
| 720 | |a Ajayi, S. O. |e author | ||
| 720 | |a Raji, Y. R. |e author | ||
| 720 | |a Salako, B. L. |e author | ||
| 720 | |a James, M. |e author | ||
| 720 | |a Zappitelli, M. |e author | ||
| 720 | |a Samuel, S. M. |e author | ||
| 260 | |c 2019 | ||
| 520 | |a Background. Epidemiological data on paediatric acute kidney injury (AKI) in sub-Saharan Africa are limited and largely retrospective. We performed a prospective study of AKI among patients admitted through the emergency room. Methods. Children admitted to the post-neonatal emergency room of the University College Hospital, Ibadan, Nigeria between February 2016 and January 2017 were studied. AKI was defined by Kidney Disease: Improving Global Outcomes serum creatinine criteria. AKI ascertainment relied on serum creatinine measurements carried out in routine care by post admission Day 1. We compared in-hospital mortality by post-admission Day 7 for patients with and without AKI (no-AKI). Results. Of the 1344 children admitted to the emergency room, 331 were included in the study. AKI occurred in 112 patients (33.8%) with a median age of 3.1 years [interquartile range (IQR) 0.9–9.4] and was Stage 3 in 50.5% of the cases. The no-AKI group had a median age of 1.8 (IQR 0.7–5.8) years. The underlying diagnoses in patients with AKI were sepsis (33.0%), malaria (12.5%) and primary renal disorders (13.4%). Twenty-four of the patients with AKI underwent dialysis: haemodialysis in 20 and peritoneal dialysis in 4. By Day 7 of admission, 7 of 98 (7.1%) patients in the AKI group had died compared with 5 of 175 (2.9%) patients in the no-AKI group [odds ratio 2.6 (95% confidence interval 0.8–8.5)]. Outcome data were not available for 58 (17.5%) patients. Conclusions. AKI is common among paediatric emergency room admissions in a tertiary care hospital in sub-Saharan Africa. It is associated with high mortality risk that may be worse in settings without dialysis. | ||
| 024 | 8 | |a 2048-8513 | |
| 024 | 8 | |a ui_art_ademola_acute_2019 | |
| 024 | 8 | |a Clinical Kidney Journal 12(4), pp. 521–526 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12206 | |
| 653 | |a acute kidney injury | ||
| 653 | |a children | ||
| 653 | |a dialysis | ||
| 653 | |a mortality | ||
| 653 | |a sub-Saharan Africa | ||
| 245 | 0 | 0 | |a Acute kidney injury among paediatric emergency room admissions in a tertiary hospital in South West Nigeria: a cohort study |