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Motor sequencing abnormalities are the trait marking neurological soft signs of schizophrenia
We describe the profile of NSS across the one-year course of schizophrenia in 84 Nigerian first-episode patients. They were assessed at baseline and 3 monthly for 12 months using the Neurological Evaluation Scale and the Positive and Negative Syndrome Scale (PANSS), and treated with flupenthixoldeca...
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| Format: | Article |
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2015
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12562 | ||
| 042 | |a dc | ||
| 720 | |a Ojagbemi, A. |e author | ||
| 720 | |a Esan, O.B. |e author | ||
| 720 | |a Emsley, R. |e author | ||
| 720 | |a Gureje, O. |e author | ||
| 260 | |c 2015 | ||
| 520 | |a We describe the profile of NSS across the one-year course of schizophrenia in 84 Nigerian first-episode patients. They were assessed at baseline and 3 monthly for 12 months using the Neurological Evaluation Scale and the Positive and Negative Syndrome Scale (PANSS), and treated with flupenthixoldecanoate. The patternofNSStotalandsub-categoryscoresobtainedfromrepeatedmeasurementswereinvestigatedfor responders (≥50% reduction of baseline PANSS scores) and non-responders using the method of repeated measures analysis of variance. Trait-like features of NSS categories were quantified using intra class correlation coefficients (ICCs). NSS were present in 96.4% of the patients at baseline (mean 21.5±11.1). The motor-sequencing sub-category was found unrelated to changes in schizophrenia psycho pathology with treatment (positive, r=0.19, p=0.136., negative, r=0.12, p=0.350; disorganization, r=0.16, p=0.245; overall, r=0.20, p=0.112). Regardless of decrements in psychopathology, motor-sequencing scores remained relatively unchanged across the course of the disease (main effects: responders’ F=2.44, p=0.930, ‘poor responders’ F=0.27, p=0.764, entire sample F=1.87, p=0.160). ICC was “substantial” at 0.8 (95% C. I=0.6–0.9). Only the motor-sequencing NSS appear to be trait marker of schizophrenia in this sample. Other NSS seem to reflect symptomatic states of the disorder. | ||
| 024 | 8 | |a 0304-3940 | |
| 024 | 8 | |a 1872-7972 | |
| 024 | 8 | |a ui_art_ojagbemi_motor_2015 | |
| 024 | 8 | |a Neuroscience Letters, 600(0), pp. 226-231 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12562 | |
| 653 | |a Schizophrenia | ||
| 653 | |a Psychopathology | ||
| 653 | |a Neurological soft signs | ||
| 653 | |a Biological markers | ||
| 245 | 0 | 0 | |a Motor sequencing abnormalities are the trait marking neurological soft signs of schizophrenia |