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Echocardiographic abnormalities and determinants of 1-month outcome of stroke among West Africans in the SIREN Study
Background-—Little is known about the relationship between echocardiographic abnormalities and outcome among patients with acute stroke. We investigated the pattern and association of baseline echocardiographic variables with 1-month disability and mortality among patients with stroke in the SIREN (...
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| Format: | Article |
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2019
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12584 | ||
| 042 | |a dc | ||
| 720 | |a Adeoye A. M. |e author | ||
| 720 | |a Ovbiagele B. |e author | ||
| 720 | |a Akinyemi J. O. |e author | ||
| 720 | |a Ogah O. S. |e author | ||
| 720 | |a Akinyemi R. |e author | ||
| 720 | |a Gebregziabher M. |e author | ||
| 720 | |a Wahab K. |e author | ||
| 720 | |a Fakunle A. G. |e author | ||
| 720 | |a Akintunde A. |e author | ||
| 720 | |a Adebayo O. |e author | ||
| 720 | |a Aje A. |e author | ||
| 720 | |a Tiwari H. K |e author | ||
| 720 | |a Arnett D. |e author | ||
| 720 | |a Agyekum F. |e author | ||
| 720 | |a Appiah L. T. |e author | ||
| 720 | |a Amusa G. |e author | ||
| 720 | |a Olunuga T. O. |e author | ||
| 720 | |a Akpa O. |e author | ||
| 720 | |a Sarfo F. S. |e author | ||
| 720 | |a Akpalu A. |e author | ||
| 720 | |a Jenkins C. |e author | ||
| 720 | |a Lackland D. |e author | ||
| 260 | |c 2019 | ||
| 520 | |a Background-—Little is known about the relationship between echocardiographic abnormalities and outcome among patients with acute stroke. We investigated the pattern and association of baseline echocardiographic variables with 1-month disability and mortality among patients with stroke in the SIREN (Stroke Investigative Research and Education Network) study. Methods and Results-—We enrolled and followed up consecutive 1020 adult patients with acute stroke with baseline transthoracic echocardiography from west Africa. To explore the relationship between echocardiographic variables and 1-month disability (using modified Rankin scale >3) and fatality, regression models were fitted. Relative risks were computed with 95% CIs. The participants comprised 60% men with a mean age of 59.2_14.6 years. Ischemic stroke was associated with smaller aortic root diameter (30.2 versus 32.5, P=0.018) and septal (16.8 versus 19.1, P<0.001) and posterior wall thickness at systole (18.9 versus 21.5, P=0.004). Over 90% of patients with stroke had abnormal left ventricular (LV) geometry with eccentric hypertrophy predominating (56.1%). Of 13 candidate variables investigated, only baseline abnormal LV geometry (concentric hypertrophy) was weakly associated with 1-month disability (unadjusted relative risk, 1.80; 95% CI, 0.97–5.73). Severe LV systolic dysfunction was significantly associated with increased 1-month mortality (unadjusted relative risk, 3.05; 95% CI, 1.36–6.83). Conclusions-—Nine of 10 patients with acute stroke had abnormal LV geometry and a third had systolic dysfunction. Severe LV systolic dysfunction was significantly associated with 1 month mortality. Larger studies are required to establish the independent effect and unravel predictive accuracy of this association | ||
| 024 | 8 | |a 2047-9980 | |
| 024 | 8 | |a ui_art_adeoye_echocardiographic_2019 | |
| 024 | 8 | |a Journal of American Heart Association 8(11), e010814 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12584 | |
| 653 | |a echocardiography | ||
| 653 | |a left ventricular geometry | ||
| 653 | |a morbidity/mortality | ||
| 653 | |a stroke | ||
| 245 | 0 | 0 | |a Echocardiographic abnormalities and determinants of 1-month outcome of stroke among West Africans in the SIREN Study |