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Neurological Soft Signs, Spontaneous and Treatment Emergent Extrapyramidal Syndromes in Black Africans With First Episode Schizophrenia
Background: Very little is known about the relationship between spontaneous and treatment-induced motor syndromes in Africans with first episode schizophrenia. Objective: We investigated the association between spontaneous NSS and EPS, with treatment-induced EPS in a homogenous sample of Black Afric...
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2018
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12719 | ||
| 042 | |a dc | ||
| 720 | |a Ojagbemi, A. |e author | ||
| 720 | |a Chiliza, B. |e author | ||
| 720 | |a Bello, T. |e author | ||
| 720 | |a Asmal, L. |e author | ||
| 720 | |a Esan, O.B. |e author | ||
| 720 | |a Emsley, R. |e author | ||
| 720 | |a Gureje, O. |e author | ||
| 260 | |c 2018 | ||
| 520 | |a Background: Very little is known about the relationship between spontaneous and treatment-induced motor syndromes in Africans with first episode schizophrenia. Objective: We investigated the association between spontaneous NSS and EPS, with treatment-induced EPS in a homogenous sample of Black Africans with first episode schizophrenia. Methods: We examined Xhosa (South Africa) and Yoruba (Nigeria) patients, using the Neurological Evaluation Scale and extrapyramidal symptoms scale before and at 3 months after exposure to low dose flupenthixol decanoate. Pearson’s correlations and Linear regression models, controlling for duration of untreated psychosis (D.U.P) and premorbid adjustments, were used in examining associations. Results: Among 99 participants in the baseline sample, 91 (91.8%) and 20 (20.2%) had at least one definite NSS and EPS, respectively, before exposure to antipsychotics. Treatment-induced EPS were recorded in 34 (38.6%). Spontaneous EPS was associated with treatment-emergent Akathisia in participants with a longer D.U.P (r = 0.75, β = 0.70, p=0.008). This association was specific for Parkinsonism (r =0.75, β=0.85, p=0.008) and dyskinesia (r = 0.75, β = 1.70, p = 0.008). Conclusion: Similar to previous findings for tardive dyskinesia in studies implementing longer-term follow-up, spontaneous EPS may also predict short-term antipsychotic induced EPS such as akathisia. These results may be important for early identification of patients at risk of treatment-induced Akathisia-linked psychomotor agitation in first episode schizophrenia. | ||
| 024 | 8 | |a 1664-0640 | |
| 024 | 8 | |a ui_art_ojagbemi_neurological_2018. | |
| 024 | 8 | |a Frontiers in Psychiatry, 9(0), pp. 172 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12719 | |
| 653 | |a Neurological examination | ||
| 653 | |a Side effects | ||
| 653 | |a Neurodevelopmental defects | ||
| 653 | |a Locomotor control | ||
| 653 | |a Tardive dyskinesia | ||
| 653 | |a African ancestry | ||
| 245 | 0 | 0 | |a Neurological Soft Signs, Spontaneous and Treatment Emergent Extrapyramidal Syndromes in Black Africans With First Episode Schizophrenia |