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Evaluation of CD4 T lymphocyte cell Levels among Hepatitis B, C and E Viruses negative individuals in Ibadan, Southwestern Nigeria
Aim: The CD4 T lymphocytes play a key role in achieving a regulated effective immune response to foreign antigens. It is also a valuable parameter for assessing HIV disease progression. However, variations in CD4 T lymphocyte values due to diverse factors have been reported. Here we evaluated CD4 T...
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2017
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12780 | ||
| 042 | |a dc | ||
| 720 | |a Adewumi, M. O . |e author | ||
| 720 | |a Omoruyi, E. C. |e author | ||
| 720 | |a Ifeorah, I. M. |e author | ||
| 720 | |a Bakarey, A. S. |e author | ||
| 720 | |a Ogunwale, A. O. |e author | ||
| 720 | |a Akere, A. |e author | ||
| 720 | |a Faleye, T. O. C. |e author | ||
| 720 | |a Adeniji, J.A. |e author | ||
| 260 | |c 2017 | ||
| 520 | |a Aim: The CD4 T lymphocytes play a key role in achieving a regulated effective immune response to foreign antigens. It is also a valuable parameter for assessing HIV disease progression. However, variations in CD4 T lymphocyte values due to diverse factors have been reported. Here we evaluated CD4 T lymphocytes among community dwellers who tested negative for hepatitis B, hepatitis C and hepatitis E viruses and compared the results with the National Reference Values (NRVs).Study Design: A cross-sectional study was conducted. Participants were enrolled using a convenient sampling technique and their socio-demographic characteristics were captured by administration of semi-structured questionnaires. Place and Duration of Study: This study was conducted among residents of Ibadan metropolis, Southwestern Nigeria. Participants were enrolled between July and September, 2013 at the University College Hospital, Ibadan. Methodology: Four hundred consenting participants who fulfilled the criteria for enrolment were evaluated for CD4 T lymphocyte counts. Results: Estimated mean CD4 T lymphocyte count of 1,183 (CD4 Range: 328-2680) cells/μl of blood was recorded for the participants. Four (1.0%), 151 (37.8%), 157 (39.2%), 74 (18.5), and 14(3.5) of the participants had CD4 T lymphocyte count ranged 352-500, 501-1,000, 1,001-1500, 1501-2,000, and >2,000 cells/μl of blood, respectively. Differences in the estimated mean CD4 count between different age groups varied significantly (P=0.010).Conclusion: In this study, significantly higher CD4 T lymphocyte values were observed among the study population in comparison to the NRVs, and consequently we advise careful interpretation and use of extrapolated CD4 T lymphocyte values in the management of persons with diverse geographical background or health conditions. | ||
| 024 | 8 | |a 2456-7043 | |
| 024 | 8 | |a 2231-0886 | |
| 024 | 8 | |a ui_art_adewumi_evaluation_2017 | |
| 024 | 8 | |a Microbiology Research Journal International 22(5), pp.1–8 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12780 | |
| 653 | |a CD4 T lymphocyte | ||
| 653 | |a HBV | ||
| 653 | |a HCV | ||
| 653 | |a HEV | ||
| 653 | |a HIV | ||
| 653 | |a Nigeria. | ||
| 245 | 0 | 0 | |a Evaluation of CD4 T lymphocyte cell Levels among Hepatitis B, C and E Viruses negative individuals in Ibadan, Southwestern Nigeria |