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Trans -resveratrol, piceatannol and gallic acid: potent polyphenols isolated from Mezoneuron benthamianum effective as anticaries, antioxidant and cytotoxic agents
Phytochemical investigation of the ethyl acetate extract of the root of Mezoneuron ben- thamianum , a shrub commonly used as chewing stick in the southwest of Nigeria, led to the isolation of three compounds characterised as trans -resveratrol, piceatannol and gallic acid by the use of spectroscopic...
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2020
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12789 | ||
| 042 | |a dc | ||
| 720 | |a Osamudiamen, P. M. |e author | ||
| 720 | |a Oluremi, B. B. |e author | ||
| 720 | |a Oderinlo, O. O. |e author | ||
| 720 | |a Aiyelaagbe, O. O. |e author | ||
| 260 | |c 2020 | ||
| 520 | |a Phytochemical investigation of the ethyl acetate extract of the root of Mezoneuron ben- thamianum , a shrub commonly used as chewing stick in the southwest of Nigeria, led to the isolation of three compounds characterised as trans -resveratrol, piceatannol and gallic acid by the use of spectroscopic techniques. The anticaries activity of the polyphenols was evaluated against four oral bacteria pathogens ( Streptococcus mutans, Pseudomonas aerugi- nosa, Staphylococcus aureus and Escherichia coli), isolated from clinical samples presented by patients having dental caries, while their antioxidant and cytotoxic activities were deter- mined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and brine shrimp ( artemia salina nau- plii) bioassay techniques. The results showed that the isolated compounds exhibited very strong anticaries activity with minimum inhibitory concentration (MIC) ranging from 25 to 300 μg/ml, antioxidant activity with IC 50 of 35.81, 30.35 and 11.73 μg/ml, when com- pared with ascorbic acid (IC 50 = 38.20 μg/ml) and cytotoxic activity with LC 50 of 7.15, 99.99 and 98.71 μg/ml for resveratrol, piceatannol and gallic acid respectively The isolated compounds demonstrated very strong anticaries, antioxidant and cytotoxic activities. This study further justifies the ethno-medicinal use of M. benthamianum as an effective tool in maintaining oral hygiene. | ||
| 024 | 8 | |a 2468-2276 | |
| 024 | 8 | |a ui_art_osamudiamen_trans-resveratrol_2020 | |
| 024 | 8 | |a Scientific African 7, pp. 1-7 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12789 | |
| 653 | |a Mezoneuron benthamianum | ||
| 653 | |a Polyphenols | ||
| 653 | |a Dental caries | ||
| 653 | |a Resveratrol | ||
| 653 | |a Piceatannol | ||
| 245 | 0 | 0 | |a Trans -resveratrol, piceatannol and gallic acid: potent polyphenols isolated from Mezoneuron benthamianum effective as anticaries, antioxidant and cytotoxic agents |