Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Rapid HIV Antigen–Antibody Assays and detection of acute HIV infection in sub-saharan Africa
Detection of acute HIV infection is a unique problem that fourth-generation HIV assays were expected to alleviate. In this commentary, we draw attention to the limitations and challenges with use of currently available rapid antigen–antibody (Ag/Ab) combination tests for detection of acute HIV infec...
Saved in:
| Format: | Article |
|---|---|
| Published: |
2019
|
| Tags: |
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000njm a2000000a 4500 | ||
|---|---|---|---|
| 001 | oai:repository.ui.edu.ng:123456789/12812 | ||
| 042 | |a dc | ||
| 720 | |a Adetunji, A. A. |e author | ||
| 720 | |a Adewumi, M. O. |e author | ||
| 720 | |a Michael, O. S. |e author | ||
| 720 | |a Fayemiwo, S. A. |e author | ||
| 720 | |a Ogunniyi, A. |e author | ||
| 720 | |a Taiwo, B. O. |e author | ||
| 260 | |c 2019 | ||
| 520 | |a Detection of acute HIV infection is a unique problem that fourth-generation HIV assays were expected to alleviate. In this commentary, we draw attention to the limitations and challenges with use of currently available rapid antigen–antibody (Ag/Ab) combination tests for detection of acute HIV infection in sub-Saharan Africa. Laboratory-based HIV-1 Ag/Ab immunoassays are complex, requiring specialized equipment and handling that are currently not affordable in many settings in Africa. The point-of-care Ag/Ab platform on the other hand is easier to deploy and potentially more accessible in resource-limited settings. However, available fourth-generation HIV-1 rapid diagnostic tests have demonstrated poor performance characteristics in field studies where non-B subtypes of HIV-1 dominate. The potential for point-of-care HIV-1 Ag/Ab diagnostics to significantly improve detection of acute HIV infection remains yet to be realized in sub-Saharan Africa. Assay platforms need to be optimized to identify local circulating subtypes, and optimal algorithms need to be determined | ||
| 024 | 8 | |a 0002‑9637 | |
| 024 | 8 | |a 1476‑1645 | |
| 024 | 8 | |a ui_art_adetunji_rapid_2019 | |
| 024 | 8 | |a The American Journal of Tropical Medicine and Hygiene 101(2), pp. 285–286 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12812 | |
| 245 | 0 | 0 | |a Rapid HIV Antigen–Antibody Assays and detection of acute HIV infection in sub-saharan Africa |