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Hiv-1 central nervous system compartmentalization and cytokine interplay in non-subtype B Hiv-1 infections in Nigeria and Malawi
"HIV-1 compartmentalization in the central nervous system (CNS) and its contribution to neurological disease have been well documented. Previous studies were conducted among people infected with subtypes B or C where CNS compartmentalization has been observed when comparing viral sequences in the bl...
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2020
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12819 | ||
| 042 | |a dc | ||
| 720 | |a Adewumi, O. M. |e author | ||
| 720 | |a Dukhovlinova, E. |e author | ||
| 720 | |a Shehu, N. Y |e author | ||
| 720 | |a Zhou, S. |e author | ||
| 720 | |a Council, O. D. |e author | ||
| 720 | |a Akanbi, M. O. |e author | ||
| 720 | |a Taiwo, B. |e author | ||
| 720 | |a Ogunniyi, A. |e author | ||
| 720 | |a Robertson, K. |e author | ||
| 720 | |a Kanyama, C. |e author | ||
| 720 | |a Hosseinipour, M. C. |e author | ||
| 720 | |a Swanstrom, R. |e author | ||
| 260 | |c 2020 | ||
| 520 | |a "HIV-1 compartmentalization in the central nervous system (CNS) and its contribution to neurological disease have been well documented. Previous studies were conducted among people infected with subtypes B or C where CNS compartmentalization has been observed when comparing viral sequences in the blood to virus in cerebrospinal fluid (CSF). However, little is known about CNS compartmentalization in other HIV-1 subtypes. Using a deep sequencing approach with Primer ID, we conducted a cross-sectional study among Nigerian and Malawian HIV-1 cohorts with or without fungal Cryptococcus infection diagnosed as cryptococcal meningitis (CM) to determine the extent of CSF/CNS compartmentalization with CM. Paired plasma and CSF samples from 45 participants were also analyzed for cytokine/chemokine levels. Viral populations comparing virus in the blood and the CSF ranged from compartmentalized to equilibrated, including minor or partial compartmentalization or clonal amplification of a single viral sequence. The frequency of compartmentalized viral populations in the blood and CSF was similar between the CM- and CM+ participants. We confirmed the potential to see compartmentalization with subtype C infection and have also documented CNS compartmentalization of an HIV-1 subtype G infection. Cytokine profiles indicated a proinflammatory environment, especially within the CSF/CNS. However, sCD163 was suppressed in the CSF in the presence of CM, perhaps due to elevated levels of IL-4, which were also a feature of the cytokine profile, showing a distinct cytokine profile with CM. | ||
| 024 | 8 | |a 0889-2229 | |
| 024 | 8 | |a 1931-8405 | |
| 024 | 8 | |a ui_art_adewumi_hiv-1_2020 | |
| 024 | 8 | |a AIDS Research and Human Retroviruses 36(16 ), pp. 490-500 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12819 | |
| 653 | |a CNS compartmentalization | ||
| 653 | |a cryptococcal meningitis | ||
| 653 | |a cytokine | ||
| 653 | |a HIV-1 | ||
| 245 | 0 | 0 | |a Hiv-1 central nervous system compartmentalization and cytokine interplay in non-subtype B Hiv-1 infections in Nigeria and Malawi |