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Serological profile of convalescent COVID-19 patients at an infectious diseases hospital in Nigeria
Background: IgG antibodies may serve as promising targets to detect and evaluate immune responses against the SARS-CoV-2 virus. Both IgA and IgM antibodies target the spike protein’s receptor binding domain and are rapidly decayed, while IgG antibodies remain relatively stable for longer periods in...
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| Format: | Article |
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| Published: |
2021
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12863 | ||
| 042 | |a dc | ||
| 720 | |a Fowotade, A. |e author | ||
| 720 | |a Fasuyi, T. O. |e author | ||
| 720 | |a Omoruyi,E. C. |e author | ||
| 720 | |a Alonge, T. O. |e author | ||
| 260 | |c 2021 | ||
| 520 | |a Background: IgG antibodies may serve as promising targets to detect and evaluate immune responses against the SARS-CoV-2 virus. Both IgA and IgM antibodies target the spike protein’s receptor binding domain and are rapidly decayed, while IgG antibodies remain relatively stable for longer periods in COVID-19 patients. Objectives: The current study was designed to detect the presence of SARS-CoV-2 antibodies among convalescent COVID-19 patients and to evaluate the relationship between these antibodies, the symptom grade and their baseline Cycle Threshold (CT) by RT-PCR. Methods: Eighty-nine convalescent COVID-19 patients on admission were recruited and tested until negative by RT-PCR. Sera obtained from participants were screened for SARS-CoV-2 IgM and IgG antibodies using rapid lateral flow assays. Results: It was observed that 93,3% and 77,5% respectively had IgM and IgG antibodies against the S1 protein of SARS-CoV-2. Majority (74,0%) presented with mild COVID-19 symptoms with a mean RT-PCR Ct value of 31,4. Conclusion: Convalescent COVID-19 patients develop a fairly good level of IgG antibodies. Theantibody status is not dependent on CT value or symptom grade. However, there was a significant correlation between baseline CT and time taken to test negative by RT-PCR. | ||
| 024 | 8 | |a 2456-7116 | |
| 024 | 8 | |a ui_art_fowotade_serological_2021 | |
| 024 | 8 | |a Journal of Advances in Microbiology 21(2), pp. 16-22 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12863 | |
| 653 | |a COVID-19 | ||
| 653 | |a cycle threshold | ||
| 653 | |a antibody | ||
| 653 | |a convalescent. | ||
| 245 | 0 | 0 | |a Serological profile of convalescent COVID-19 patients at an infectious diseases hospital in Nigeria |