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The african female Breast Cancer Epidemiology study protocol
Breast cancer is now the commonest cancer in most sub-Saharan African countries. Few studies of the epidemiology and genomics of breast cancer and its molecular subtypes in these countries have been done. The African Female Breast Cancer Epidemiology (AFBRECANE) study, a part of the Human Heredity a...
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| Format: | Article |
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2022-04
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/12872 | ||
| 042 | |a dc | ||
| 720 | |a Ezeome, E. R. |e author | ||
| 720 | |a Yawe, K.-D. T. |e author | ||
| 720 | |a Ayandipo, O. |e author | ||
| 720 | |a Badejo, O. |e author | ||
| 720 | |a Adebamowo, S. N. |e author | ||
| 720 | |a Achusi, B. |e author | ||
| 720 | |a Fowotade, A. |e author | ||
| 720 | |a Ogun, G. |e author | ||
| 720 | |a Adebamowo, C. A. |e author | ||
| 260 | |c 2022-04 | ||
| 520 | |a Breast cancer is now the commonest cancer in most sub-Saharan African countries. Few studies of the epidemiology and genomics of breast cancer and its molecular subtypes in these countries have been done. The African Female Breast Cancer Epidemiology (AFBRECANE) study, a part of the Human Heredity and Health in Africa (H3Africa) initiative, is designed to study the genomics and epidemiology of breast cancer and its molecular subtypes in Nigerian women. We link recruitment of breast cancer cases at study sites with population-based cancer registries activities to enable ascertainment of the incidence of breast cancer and its molecular subtypes. We use centralized laboratory processing to characterize the histopathological and molecular diagnosis of breast cancer and its subtypes using multiple technologies. By combining genome-wide association study (GWAS) data from this study with that generated from 12,000 women participating in our prospective cohort study of cervical cancer, we conduct GWAS of breast cancer in an entirely indigenous African population. We test associations between dietary intakes and breast cancer and focus on vitamin D which we measure using dietary intakes, serum vitamin D, and Mendelian randomization. This paper describes the AFBRECANE project, its design, objectives and anticipated contributions to knowledge and understanding of breast cancer. | ||
| 024 | 8 | |a 2234-943X | |
| 024 | 8 | |a ui_art_ezeome_african_2022 | |
| 024 | 8 | |a Frontiers in Oncology 12(856182), pp. 1-11 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/12872 | |
| 653 | |a breast cancer | ||
| 653 | |a female | ||
| 653 | |a Africa | ||
| 653 | |a genomics | ||
| 653 | |a epidemiology | ||
| 245 | 0 | 0 | |a The african female Breast Cancer Epidemiology study protocol |