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Development of directly compressible excipients from Phoenix dactylifera (Date) mucilage and microcrystalline cellulose using co-processing techniques
The objective of this study was to harness the excipient potential of date mucilage by co-grinding and co-fusing with avicel for enhanced performance in the directcompression of metronidazole. Co-grinding and co-fusing of parent polymers were done using established methods and excipients were used i...
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| Format: | Article |
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2018
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/13260 | ||
| 042 | |a dc | ||
| 720 | |a Akin-Ajani, O. D |e author | ||
| 720 | |a Ajala, T. O |e author | ||
| 720 | |a Okoli, U. M. |e author | ||
| 720 | |a Okonta, O |e author | ||
| 260 | |c 2018 | ||
| 520 | |a The objective of this study was to harness the excipient potential of date mucilage by co-grinding and co-fusing with avicel for enhanced performance in the directcompression of metronidazole. Co-grinding and co-fusing of parent polymers were done using established methods and excipients were used in the direct-compression of metronidazole tablets. The shape and surface morphology of the particles of date mucilage (DAM) and co-processed excipients were generally granular, rough and irregular. There was a significant improvement in the disintegration of tablets prepared using the coprocessed excipients in comparison to that prepared using DAM alone. The disintegration time for tablets prepared using co-fused excipients was lower than that of co-grinded additives although the differences were not significant (p > 0.05). Generally, the co-processed excipients improved the mechanical and disintegration properties of the tablets produced compared to tablets prepared using DAM alone and could be further developed as direct compression excipients | ||
| 024 | 8 | |a 2636‑8552 | |
| 024 | 8 | |a ui_art_akin-ajani_development_2018 | |
| 024 | 8 | |a Acta Pharmaceutica Sciencia 56(3) P.7 – 25 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/13260 | |
| 653 | |a Date mucilage | ||
| 653 | |a avicel | ||
| 653 | |a co-processing | ||
| 653 | |a metronidazole tablets. | ||
| 245 | 0 | 0 | |a Development of directly compressible excipients from Phoenix dactylifera (Date) mucilage and microcrystalline cellulose using co-processing techniques |