Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Alterations in blood pressure, antioxidant status and caspase 8expression in cobalt chloride-induced cardio-renal dysfunction arereversed by Ocimum gratissimum and gallic acid in Wistar rats
The protective abilities of the chloroform extract of Ocimum gratissimum (COG) and gallic acid againstcobalt chloride (CoCl2) − induced cardiac and renal toxicity were evaluated. Rats were exposed to CoCl2(350 ppm) for 7 days, either alone, or in combination with COG (100 and 200 mg/kg) or gallic ac...
Saved in:
| Format: | Article |
|---|---|
| Published: |
2016
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000njm a2000000a 4500 | ||
|---|---|---|---|
| 001 | oai:repository.ui.edu.ng:123456789/13352 | ||
| 042 | |a dc | ||
| 720 | |a Akinrinde, A. S. |e author | ||
| 720 | |a Oyagbemi, A. A. |e author | ||
| 720 | |a Omobowale, T. O. |e author | ||
| 720 | |a Asenuga, E. R. |e author | ||
| 720 | |a Ajibade, T. O. |e author | ||
| 260 | |c 2016 | ||
| 520 | |a The protective abilities of the chloroform extract of Ocimum gratissimum (COG) and gallic acid againstcobalt chloride (CoCl2) − induced cardiac and renal toxicity were evaluated. Rats were exposed to CoCl2(350 ppm) for 7 days, either alone, or in combination with COG (100 and 200 mg/kg) or gallic acid(120 mg/kg). CoCl2given alone, caused significant increases (p < 0.05) in oxidative stress parameters(hydrogen peroxide, H2O2and malondialdehyde, MDA) and increased expression of the apoptotic initia-tor caspase 8 in the heart and kidneys. There was significant reduction (p < 0.05) in reduced glutathione(GSH) in cardiac and renal tissues; reduction in superoxide dismutase (SOD) activity in the kidneys andadaptive increases in Glutathione S-transferase (GST) and catalase (CAT). CoCl2also produced signifi-cant reduction (p < 0.05) in systolic (SBP), diastolic (DBP) and mean arterial (MAP) blood pressures. OralCOG and gallic acid treatment significantly reduced (p < 0.05) the levels of H2O2and MDA; with reducedexpression of caspase 8 and restoration of GSH levels, GPx, SOD and CAT activities, howbeit, to varyingdegrees in the heart and kidneys. COG (200 mg/kg) was most effective in restoring the blood pressures inthe rats to near control levels. CoCl2-induced histopathological lesions including myocardial infarctionand inflammation and renal tubular necrosis and inflammation were effectively ameliorated by the treat-ments administered. This study provides evidence for the protective roles of O. gratissimum and gallicacid by modulation of CoCl2-induced alterations in blood pressure, antioxidant status and pro-apoptoticcaspase 8 in Wistar rats. | ||
| 024 | 8 | |a 0946-672X | |
| 024 | 8 | |a 1878-3252 | |
| 024 | 8 | |a ui_art_akinrinde_alterations_2016 | |
| 024 | 8 | |a Journal of Trace Elements in Medicine and Biology 36, pp. 27-37 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/13352 | |
| 653 | |a Cobalt | ||
| 653 | |a Gallic acid | ||
| 653 | |a Ocimum gratissimum | ||
| 653 | |a Oxidative stress | ||
| 653 | |a Heart | ||
| 653 | |a Kidneys | ||
| 653 | |a Apoptosis | ||
| 653 | |a Blood pressure | ||
| 245 | 0 | 0 | |a Alterations in blood pressure, antioxidant status and caspase 8expression in cobalt chloride-induced cardio-renal dysfunction arereversed by Ocimum gratissimum and gallic acid in Wistar rats |