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Effects of Co-administration of Extracts of Carica papaya Linn (Fam: Caricaceae) on Activity of Two Oral Hypoglycaemic Agents
Purpose: To investigate the interacting effects of co-administration of Carica papaya leaf extract on the hypoglycemic activity of metformin and glimepiride in an animal model. Method: Experimental factorial design was used to evaluate the individual and interaction influence of three variables ie n...
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| Format: | Article |
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2007
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/13615 | ||
| 042 | |a dc | ||
| 720 | |a Fakeye, T.O. |e author | ||
| 720 | |a Oladipupo, T. |e author | ||
| 720 | |a Showande, J.S. |e author | ||
| 720 | |a Ogunremi, Y |e author | ||
| 260 | |c 2007 | ||
| 520 | |a Purpose: To investigate the interacting effects of co-administration of Carica papaya leaf extract on the hypoglycemic activity of metformin and glimepiride in an animal model. Method: Experimental factorial design was used to evaluate the individual and interaction influence of three variables ie nature (N), dose administered (C) and duration of administration (D), in a 23(=8) employed at two levels - ‘’high’’ and ‘‘low’’ - on blood glucose of diabetic rats on administration of ethanolic leaf extract of Carica papaya and two hypoglycemic agents, metformin and glimepiride. Unpaired t-test was used to test for significant difference due to administration of the combination Results: Extract of Carica papaya at 5.0 mg/kg produced significant blood glucose reduction with no significant reduction at the higher dose of 10 mg/kg (p>0.05). Changing nature from “low” (Carica papaya extract) to “high” (glimepiride or metformin) did not significantly change hypoglycemic activity. Generally, the ranking of the interacting effects was ND>CD>>NC for glimepiride/extract, and CD>ND>NC for metformin/extract. Administration of higher dose of the extract led to significant (p<0.01) increase in onset of activity of glimepiride. The onset of activity of metformin was not affected, but a significant lowering (p<0.05) of blood glucose was observed at 24 hr with all combinations of extract and metformin. Conclusion: Leaf extract of Carica papaya significantly delays the onset of hypoglycaemic activity of glimepiride, and increases the hypoglycaemic effect of metformin with the variablesinteracting differently for each drug-extract combinations. | ||
| 024 | 8 | |a 1596-9827 | |
| 024 | 8 | |a 1596-5996 | |
| 024 | 8 | |a ui_art_fakeye_effects_2007 | |
| 024 | 8 | |a Tropical Journal of Pharmaceutical Research 6(1), pp. 671–678 | |
| 024 | 8 | |a https://repository.ui.edu.ng/handle/123456789/13615 | |
| 653 | |a Carica Papaya Extract | ||
| 653 | |a Glimepiride | ||
| 653 | |a Metformin | ||
| 653 | |a Interaction | ||
| 653 | |a Blood Glucose | ||
| 653 | |a Mice | ||
| 245 | 0 | 0 | |a Effects of Co-administration of Extracts of Carica papaya Linn (Fam: Caricaceae) on Activity of Two Oral Hypoglycaemic Agents |