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Respiratory syncytial virus infection: denominator-based studies in Indonesia, Mozambique, Nigeria and South Africa
OBJECTIVE:To assess the burden of respiratory syncytial virus (RSV)-associated lower respiratory infections (LRI) in children in four developing countries.METHODS:A WHO protocol for prospective population-based surveillance of acute respiratory infections in children aged less than 5 years was used...
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| Format: | Article |
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2004
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/2295 | ||
| 042 | |a dc | ||
| 720 | |a Robertson, S. E. |e author | ||
| 720 | |a Roca, A. |e author | ||
| 720 | |a Alonso, P. |e author | ||
| 720 | |a Simoes, E. A. F. |e author | ||
| 720 | |a Kartasasmita, C. B. |e author | ||
| 720 | |a Olaleye, D. O. |e author | ||
| 720 | |a Odaibo, G. N. |e author | ||
| 720 | |a Collinson, M. |e author | ||
| 720 | |a Venter, M. |e author | ||
| 720 | |a Zhu, Y. |e author | ||
| 720 | |a Wright, P. F. |e author | ||
| 260 | |c 2004 | ||
| 520 | |a OBJECTIVE:To assess the burden of respiratory syncytial virus (RSV)-associated lower respiratory infections (LRI) in children in four developing countries.METHODS:A WHO protocol for prospective population-based surveillance of acute respiratory infections in children aged less than 5 years was used at sites in Indonesia, Mozambique, Nigeria and South Africa. RSV antigen was identified by enzyme-linked immunosorbent assay performed on nasopharyngeal specimens from children meeting clinical case definitions.FINDINGS:Among children aged < 5 years, the incidence of RSV-associated LRI per 1000 child-years was 34 in Indonesia and 94 in Nigeria. The incidence of RSV-associated severe LRI per 1000 child-years was 5 in Mozambique, 10 in Indonesia, and 9 in South Africa. At all study sites, the majority of RSV cases occurred in infants.CONCLUSION:These studies demonstrate that RSV contributes to a substantial but quite variable burden of LRI in children aged < 5 years in four developing countries. The possible explanations for this variation include social factors, such as family size and patterns of seeking health care; the proportion of children infected by human immunodeficiency syndrome (HIV); and differences in clinical definitions used for obtaining samples. The age distribution of cases indicates the need for an RSV vaccine that can protect children early in life. | ||
| 024 | 8 | |a Bulletin of the World Health Organization 82(12) pp.914-922 | |
| 024 | 8 | |a http://ir.library.ui.edu.ng/handle/123456789/2295 | |
| 245 | 0 | 0 | |a Respiratory syncytial virus infection: denominator-based studies in Indonesia, Mozambique, Nigeria and South Africa |