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Occult HBV infection among a cohort of Nigerian adults
"OBJECTIVE:To determine markers of HBV infection and detect the presence of its occult infection in serum of a cohort of adult Nigerians. METHODOLOGY:The study involved 28 adult Nigerians with viral hepatitis (Group 1) and 28 apparently healthy adult Nigerians as controls (Group 2). Their sera were...
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2009
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/2454 | ||
| 042 | |a dc | ||
| 720 | |a Ola, S. O. |e author | ||
| 720 | |a Otegbayo, J. A. |e author | ||
| 720 | |a Odaibo, G. N. |e author | ||
| 720 | |a Olaleye, D. O. |e author | ||
| 720 | |a Summerton, C. B. |e author | ||
| 720 | |a Bamgboye, E. A. |e author | ||
| 260 | |c 2009 | ||
| 520 | |a "OBJECTIVE:To determine markers of HBV infection and detect the presence of its occult infection in serum of a cohort of adult Nigerians. METHODOLOGY:The study involved 28 adult Nigerians with viral hepatitis (Group 1) and 28 apparently healthy adult Nigerians as controls (Group 2). Their sera were assayed for HBsAg, HBeAg, anti-HBe, anti-HBc, anti-HBs, and anti-HCV, while HBV DNA was determined in 15 patients with chronic hepatitis. Significance of differences between the patients and control subjects was assessed using Chi-square test at a 95% confidence level. RESULTS:Sero-detection of HBsAg, HBeAg, anti-HBe and anti-HBc was higher among the patients compared to the controls. HBV infection was diagnosed by HBsAg (89%) and a duo of HBsAg and anti-HBc (100%) among the patients. Similarly, eleven and four types of different patterns of HBV markers were observed among the respective groups. Anti-HBe (9.5%), anti-HBc (14.3%), and anti-HBs (9.5%) were detected among all the subjects who were sero-negative for HBsAg. HBV DNA was also detected in 86.7% of the 15 patients with chronic hepatitis, while occult HBV infection was observed in 7.2% of the patients and none (0%) of the controls, p < 0.05. Furthermore, HCV infection occurred among subjects with all the different patterns of HBV markers, except those with occult HBV infection and natural immunity to HBV. CONCLUSION:This study shows that occult HBV infection is present among Nigerian adults and determination of HBsAg, anti-HBc, anti-HBe, and HBV DNA will assist in its detection." | ||
| 024 | 8 | |a Journal of Infection in developing Countries 3(6), pp. 442-446 | |
| 024 | 8 | |a http://ir.library.ui.edu.ng/handle/123456789/2454 | |
| 653 | |a occult HBV infection, | ||
| 653 | |a HCV, | ||
| 653 | |a Nigerians | ||
| 245 | 0 | 0 | |a Occult HBV infection among a cohort of Nigerian adults |