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Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft
Background: The use of conjunctiva autograft, adjunct antimetabolite therapy has been shown to be effective in preventing pterygium recurrence. Objective: To compare 5 fluorouracil (5-FU) to conjunctival autograft in the treatment of large, fleshy pterygium. Methods: A randomised controlled prospect...
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2008
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/2652 | ||
| 042 | |a dc | ||
| 720 | |a Bekibele, C. O. |e author | ||
| 720 | |a Baiyeroju A.M.|| Olusanya, B. A. |e author | ||
| 720 | |a Ashaye, A.O. |e author | ||
| 720 | |a Oluleye, T. S. |e author | ||
| 260 | |c 2008 | ||
| 520 | |a Background: The use of conjunctiva autograft, adjunct antimetabolite therapy has been shown to be effective in preventing pterygium recurrence. Objective: To compare 5 fluorouracil (5-FU) to conjunctival autograft in the treatment of large, fleshy pterygium. Methods: A randomised controlled prospective study of outcome of pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft. Thirty-five eyes with large pterygium treated with bare sclera conjunctival excision plus 5-FU were compared with 33 eyes treated with excision and conjunctival autograft alone. Results: Post-operative pterygium recurrence was observed in four (11.4%) eyes treated with 5-FU and 4 (12.1%) eyes treated with conjunctiva autograft (P>0.05). The post-operative complications included, granuloma formation 11.4% for 5-FU and 3.0% for autograft and conjunctival discharge 5.7% for 5-FU group only. Conclusion: 5-FU is marginally superior to conjunctival autograft in the prevention of pterygium recurrence but neither gives a more desirable single digit recurrence rate. Randomised studies combining both conjunctival autograft and 5-FU in pterygium treatment is advocated to further explore their effect. | ||
| 024 | 8 | |a 0905-222X | |
| 024 | 8 | |a Eye 22, pp. 31-34 | |
| 024 | 8 | |a http://ir.library.ui.edu.ng/handle/123456789/2652 | |
| 653 | |a fleshy pterygium; | ||
| 653 | |a pterygium recurrence; | ||
| 653 | |a 5-fluorouracil; | ||
| 653 | |a conjunctival autograft | ||
| 245 | 0 | 0 | |a Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft |