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In-vitro Bactericidal Kinetics of Chlorhexidine Gluconate Disinfectant/ Antiseptic Formulations Containing Different Additives
Chlorhexidine gluconate(CHG) is a popular disinfectant/antiseptic which is often formulated with additives. We investigated the effect of additives type on the in vitro bactericidal kinetics of CHG in three commercially available formulations: Hibiscrub®, Savlon® and Purit® commonly used as househol...
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| Format: | Article |
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2014-01
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| LEADER | 00000njm a2000000a 4500 | ||
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| 001 | oai:repository.ui.edu.ng:123456789/2974 | ||
| 042 | |a dc | ||
| 720 | |a Idowu, P. A. |e author | ||
| 720 | |a Idowu, O. S. |e author | ||
| 260 | |c 2014-01 | ||
| 520 | |a Chlorhexidine gluconate(CHG) is a popular disinfectant/antiseptic which is often formulated with additives. We investigated the effect of additives type on the in vitro bactericidal kinetics of CHG in three commercially available formulations: Hibiscrub®, Savlon® and Purit® commonly used as household and hospital disinfectants/antiseptics. The bactericidal kinetics of the products was determined by time-survival curve method using Pseudomonas aeruginosa NCTC 6750 and Staphylococcus aureus NCTC 6571 as model organisms. Best-fit rate constant and half-life was computed by exponential decay curve-fitting. Half-life was; 76.5, 65.5, 66 and 74 (min) for Control solution, Hibiscrub®, Savlon® and Purit® respectively, against Ps. aeruginosa. The corresponding values obtained against Staph. aureus are 51.0, 61.7, 29.3, and 49.0 (min) (95% CI). Presence of alcohol (e.g. Hibiscrub® and Savlon®) caused an insignificant increase in the rate of killing of Ps. aeruginosa relative to preparations that are devoid of alcohol. (p>0.05, 1-way ANOVA). Toward Staphylococcus aureus, the combined effect of cetrimide and alcohol (e.g. Savlon®) is higher than any enhancement due to combination of alcohol and surfactant (e.g. Hibiscrub). Savlon® show a significantly higher bactericidal effect of all the preparations (P<0.0001, 1-way ANOVA). The choice of additives in the formulation of chlorhexidine antiseptic solutions significantly alters the kinetics and overall bactericidal effect of CHG towards Staphylococcus aureus but not Pseudomonas areruginosa. | ||
| 024 | 8 | |a 1119-5096 | |
| 024 | 8 | |a African Journal Biomedical Research 17(1), pp. 37-42 | |
| 024 | 8 | |a ui_art_idowu_in-vitro_2014 | |
| 024 | 8 | |a http://ir.library.ui.edu.ng/handle/123456789/2974 | |
| 653 | |a Chlorhexidine gluconate | ||
| 653 | |a savlon | ||
| 653 | |a hibiscrub | ||
| 653 | |a purit | ||
| 653 | |a bactericidal kinetics | ||
| 245 | 0 | 0 | |a In-vitro Bactericidal Kinetics of Chlorhexidine Gluconate Disinfectant/ Antiseptic Formulations Containing Different Additives |