Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
In-vitro antimalarial activities of withania somnifera, gymnema sylvestre, ocimum gratisimum and cajanus cajan
A study was carried out to determine the efficacy of four plants, Withania somnifera (WS), Gymnema sylvestre (GS), Ocimum gratisimum (OG) and Cajanus cajan (CC) traditionally used in the treatment of malaria in Nigeria and India. Ethanolic extracts of these plants were tested in vitro on choloroquin...
Saved in:
| Format: | Conference Proceeding |
|---|---|
| Published: |
2010-08
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
MARC
| LEADER | 00000njm a2000000a 4500 | ||
|---|---|---|---|
| 001 | oai:repository.ui.edu.ng:123456789/5696 | ||
| 042 | |a dc | ||
| 720 | |a Morenikeji, O. A. |e author | ||
| 720 | |a Pillai, C. R. |e author | ||
| 720 | |a Vakcha, N. |e author | ||
| 720 | |a Dash, A. P. |e author | ||
| 260 | |c 2010-08 | ||
| 520 | |a A study was carried out to determine the efficacy of four plants, Withania somnifera (WS), Gymnema sylvestre (GS), Ocimum gratisimum (OG) and Cajanus cajan (CC) traditionally used in the treatment of malaria in Nigeria and India. Ethanolic extracts of these plants were tested in vitro on choloroquine sensitive (MRC-pf-2) and resistant (MRC-pf-303) strains of Plasmodium falciparum for their anti-malarial activity. The IC(50) values of these plants were calculated and found to be OG (IC(50) = 23.48 µg/ ml), WS (IC(50)= 45.24 µg/ ml), GS (IC(50) = 45.25 µg/ ml) for the pf sensitive strain and CC (IC(50) = 47.52 µg/ ml) in the pf resistant strain. Others, GS IC(50) = 69.70 µg/ ml (resistant strain), CC IC(50) = 72.3lµg/ ml (sensitive strain), WS IC(50)= 88.30 µg/ ml (resistant strain), OG IC(50)= 121.76µg/ ml (resistant strain). Higher concentrations caused total inhibition of the parasite at the ring stage. Ocimum gratisimum showed the most significant antimalarial effect on the parasites sensitive strain. Results lend some credence to the use of medicinal plants in the treatment of malaria and the need to study the active constituents of effective ones. | ||
| 024 | 8 | |a ui_inpro_morenikeji_in-vitro_2010 | |
| 024 | 8 | |a 12th International Congress of Parasitology, held at Melbourne, Australia, between August 15-20, pp. 175-180 | |
| 024 | 8 | |a http://ir.library.ui.edu.ng/handle/123456789/5696 | |
| 653 | |a In-vitro studies | ||
| 653 | |a Plasmodium falciparum | ||
| 653 | |a Medicinal plants | ||
| 245 | 0 | 0 | |a In-vitro antimalarial activities of withania somnifera, gymnema sylvestre, ocimum gratisimum and cajanus cajan |